Evidence map›Paper›PMID 34427183›Full record

ArticleeLife2021

Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses.

Gülçin Vardar, Andrea Salazar-Lázaro, Marisa Brockmann, Marion Weber-Boyvat, Sina Zobel, Victor Wumbor-Apin Kumbol, Thorsten Trimbuch, Christian Rosenmund

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Munc18 reprograms the intrinsic neuronal SNARE complex assembly pathway.bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. A De Novo Splicing Mutation ofInternational journal of molecular sciences · 2024
    Article
  10. Syntaxin 3B: A SNARE Protein Required for Vision.International journal of molecular sciences · 2024
    Review
  11. Article
  12. SNARE Proteins in Synaptic Vesicle Fusion.Advances in neurobiology · 2023
    Article
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gülçin VardarUniversität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-5295-1591
Andrea Salazar-LázaroUniversität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Marisa BrockmannUniversität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-1386-5359
Marion Weber-BoyvatUniversität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Sina ZobelUniversität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Victor Wumbor-Apin KumbolEinstein Center for Neurosciences Berlin, Berlin, Germany.
Thorsten TrimbuchUniversität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Christian RosenmundUniversität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-3905-2444
Humboldt-Universität zu Berlin · DEEinstein Center for Neurosciences Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Syntaxin-1 (STX1) and Munc18-1 are two requisite components of synaptic vesicular release machinery, so much so synaptic transmission cannot proceed in their absence. They form a tight complex through two major binding modes: through STX1's N-peptide and through STX1's closed conformation driven by its H

Indexed as

AnimalsBiological TransportCells, CulturedMembrane FusionMiceMunc18 ProteinsNeuronsPeptidesProtein BindingProtein ConformationSynapsesSynaptic TransmissionSynaptic VesiclesSyntaxin 1Munc18 ProteinsPeptidesStx1a protein, mouseStxbp1 protein, mouseSyntaxin 1habc-domainleopen conformationmouseMunc18-1neuroscienceN-peptidesynaptic transmissionsyntaxin-1

Identifiers

PMID34427183
PMCPMC8416022
OpenAlexW3194753673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.