Evidence map›Paper›PMID 34427144›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Analysis of L-leucine amino acid transporter species activity and gene expression by human blood brain barrier hCMEC/D3 model reveal potential LAT1, LAT4, B

Mehdi Taslimifar, Martin Faltys, Vartan Kurtcuoglu, François Verrey, Victoria Makrides

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Mehdi TaslimifarThe Interface Group, Institute of Physiology, University of Zürich, Zürich, Switzerland.
Martin FaltysEpithelial Transport Group, Institute of Physiology, University of Zürich, Zürich, Switzerland.
Vartan KurtcuogluThe Interface Group, Institute of Physiology, University of Zürich, Zürich, Switzerland.
François VerreyEpithelial Transport Group, Institute of Physiology, University of Zürich, Zürich, Switzerland.
Victoria MakridesThe Interface Group, Institute of Physiology, University of Zürich, Zürich, Switzerland.
University of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the CNS, amino acid (AA) neurotransmitters and neurotransmitter precursors are subject to tight homeostatic control mediated by blood-brain barrier (BBB) solute carrier amino acid transporters (AATs). Since the BBB is composed of multiple closely apposed cell types and opportunities for human

Indexed as

Gene Expression RegulationModels, NeurologicalAmino Acid Transport Systems, NeutralAmino Acid Transport System y+LBlood-Brain BarrierCell LineEndothelial CellsFusion Regulatory Protein 1, Heavy ChainHumansLarge Neutral Amino Acid-Transporter 1LeucineNerve Tissue ProteinsAmino Acid Transport Systems, NeutralAmino Acid Transport System y+LFusion Regulatory Protein 1, Heavy ChainLarge Neutral Amino Acid-Transporter 1LeucineNerve Tissue ProteinsSLC3A2 protein, humanSLC6A15 protein, humanSLC7A5 protein, humanSLC7A7 protein, humanBlood-brain barriercomputational modelhCMEC/D3insulin-like growth factor 1solute carrier amino acid transporters

Identifiers

PMID34427144
PMCPMC8721536
OpenAlexW3193626437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.