Evidence map›Paper›PMID 34427038›Full record

ArticleGenes, brain, and behavior2021

An assessment of executive function in two different rat models of attention-deficit hyperactivity disorder: Spontaneously hypertensive versus Lphn3 knockout rats.

Helen J K Sable, Deranda B Lester, Joshua L Potter, Hunter G Nolen, Destinee M Cruthird, Lauren M Estes, Alyssa D Johnson, Samantha L Regan, Michael T Williams, Charles V Vorhees

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, brain, and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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  10. Review of rodent models of attention deficit hyperactivity disorder.Neuroscience and biobehavioral reviews · 2022
    Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Helen J K SableDepartment of Psychology, University of Memphis, Memphis, Tennessee, USA.ORCID 0000-0003-0768-9544
Deranda B LesterDepartment of Psychology, University of Memphis, Memphis, Tennessee, USA.
Joshua L PotterDepartment of Psychology, University of Memphis, Memphis, Tennessee, USA.
Hunter G NolenDepartment of Psychology, University of Memphis, Memphis, Tennessee, USA.
Destinee M CruthirdDepartment of Psychology, University of Memphis, Memphis, Tennessee, USA.
Lauren M EstesDepartment of Psychology, University of Memphis, Memphis, Tennessee, USA.
Alyssa D JohnsonDepartment of Psychology, University of Memphis, Memphis, Tennessee, USA.
Samantha L ReganDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Michael T WilliamsDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0001-9841-9683
Charles V VorheesDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0003-3558-8812
University of Memphis · USCincinnati Children's Hospital Medical Center · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Gene-pesticide interactions and ADHDR01ES032270 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI VORHEES, CHARLES V, WILLIAMS, MICHAEL T · 2020 to 2024
$2.2M
NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R01 ES032270NIEHS NIH HHS R01ES032270
6 · The paper itself

Abstract

Attention-deficit/hyperactivity disorder (ADHD) a common neurodevelopmental disorder of childhood and often comorbid with other externalizing disorders (EDs). There is evidence that externalizing behaviors share a common genetic etiology. Recently, a genome-wide, multigenerational sample linked variants in the Lphn3 gene to ADHD and other externalizing behaviors. Likewise, limited research in animal models has provided converging evidence that Lphn3 plays a role in EDs. This study examined the impact of Lphn3 deletion (i.e., Lphn3

Indexed as

Attention Deficit Disorder with HyperactivityDisease Models, AnimalExecutive FunctionAnimalsFemaleGene DeletionMaleRatsRats, Inbred SHRRats, Sprague-DawleyReceptors, G-Protein-CoupledReceptors, PeptideSpatial Behaviorlphn3 protein, ratReceptors, G-Protein-CoupledReceptors, PeptideAdgrl3ADHDCRISPR/Cas9delayed spatial alternationdifferential reinforcement of low ratesexternalizing behaviorinhibitory controlLatrophilin-3Lphn3working memory

Identifiers

PMID34427038
PMCPMC10114166
OpenAlexW3194148946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.