Evidence map›Paper›PMID 34426916›Full record

ArticleDoklady. Biochemistry and biophysics2021

Mutations of Phosphorylation Sites in MSL1 Protein Do Not Affect Dosage Compensation in Drosophila melanogaster.

V A Babosha, P G Georgiev, O G Maksimenko

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

V A BaboshaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
P G GeorgievInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
O G MaksimenkoInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. maksog@mail.ru.
Institute of Gene Biology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteins MSL1 and MSL2 form the core of the Drosophila dosage compensation complex, which specifically binds to the X chromosome of males. Phosphorylation of certain amino acid residues was previously shown to regulate MSL1 activity. In the present work, transgenic lines of Drosophila expressing mutant variants of the MSL1 protein were obtained, in which amino acids undergoing phosphorylation were replaced. As a result, it was shown that inactivation of phosphorylation sites does not affect the efficiency of specific binding of the dosage compensation complex to the X chromosome of males and its functional activity.

Indexed as

Dosage Compensation, GeneticDrosophila melanogasterDrosophila ProteinsMutationAnimalsAnimals, Genetically ModifiedDNA-Binding ProteinsMaleNuclear ProteinsPhosphorylationTranscription FactorsX ChromosomeDNA-Binding ProteinsDrosophila Proteinsmsl-1 protein, DrosophilaNuclear ProteinsTranscription Factorsdosage compensationDrosophilaMSL1phosphorylationpolytene chromosomestranscription regulation

Identifiers

PMID34426916
OpenAlexW3193555304

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.