Evidence map›Paper›PMID 34426817›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Household Transmission and Clinical Features of SARS-CoV-2 Infections by Age in 2 US Communities.

Huong Q McLean, Carlos G Grijalva, Kayla E Hanson, Yuwei G Zhu, Jessica E Deyoe, Jennifer K Meece, Natasha B Halasa, James D Chappell, Alexandra Mellis, Carrie Reed and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Huong Q McLeanMarshfield Clinic Research Institute, Marshfield, Wisconsin.
Carlos G GrijalvaVanderbilt University Medical Center, Nashville, Tennessee.
Kayla E HansonMarshfield Clinic Research Institute, Marshfield, Wisconsin.
Yuwei G ZhuVanderbilt University Medical Center, Nashville, Tennessee.
Jessica E DeyoeCenters for Disease Control and Prevention, Atlanta, Georgia.
Jennifer K MeeceMarshfield Clinic Research Institute, Marshfield, Wisconsin.
Natasha B HalasaVanderbilt University Medical Center, Nashville, Tennessee.
James D ChappellVanderbilt University Medical Center, Nashville, Tennessee.
Alexandra MellisCenters for Disease Control and Prevention, Atlanta, Georgia.
Carrie ReedCenters for Disease Control and Prevention, Atlanta, Georgia.
Edward A BelongiaMarshfield Clinic Research Institute, Marshfield, Wisconsin.
H Keipp TalbotVanderbilt University Medical Center, Nashville, Tennessee.
Melissa A RolfesCenters for Disease Control and Prevention, Atlanta, Georgia.
Vanderbilt University Medical Center · USCenters for Disease Control and Prevention · USMarshfield Clinic · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Household Transmission of Influenza Viruses in the Community-COVID 19 SupplementU01IP001083 · IP · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRIJALVA, CARLOS G, TALBOT, HELEN KEIPP · 2017 to 2019
$2.2M
Household Transmisson of Influenza Viruses in the CommunityU01IP001078 · IP · MARSHFIELD CLINIC RESEARCH FOUNDATION · PI NGUYEN, HUONG Q · 2017 to 2019
$2.0M
Mentoring in transmission of influenza and strategies for preventionK24AI148459 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRIJALVA, CARLOS G · 2020 to 2024
$893k
ACL HHS U01IP001078ACL HHS U01IP001083NCATS NIH HHS UL1 TR002243NCIRD CDC HHS U01 IP001078NCIRD CDC HHS U01 IP001083NIAID NIH HHS K24 AI148459
6 · The paper itself

Abstract

objectivesExamine age differences in SARS-CoV-2 transmission risk from primary cases and infection risk among household contacts, and symptoms among those with SARS-CoV-2 infection.

methodsPeople with SARS-CoV-2 infection in Nashville, Tennessee and central and western Wisconsin and their household contacts were followed daily for 14 days to ascertain symptoms and secondary transmission events. Households were enrolled between April 2020 and April 2021. Secondary infection risks (SIR) by age of the primary case and contacts were estimated using generalized estimating equations.

resultsThe 226 primary cases were followed by 198 (49%) secondary SARS-CoV-2 infections among 404 household contacts. Age group-specific SIR among contacts ranged from 36% to 53%, with no differences by age. SIR was lower from primary cases aged 12-17 years than from primary cases 18-49 years (risk ratio [RR] 0.42; 95% confidence interval [CI] 0.19-0.91). SIR was 55% and 45%, respectively, among primary case-contact pairs in the same versus different age group (RR 1.47; 95% CI 0.98-2.22). SIR was highest among primary case-contacts pairs aged ≥65 years (76%) and 5-11 years (69%). Among secondary SARS-CoV-2 infections, 19% were asymptomatic; there was no difference in the frequency of asymptomatic infections by age group.

conclusionsBoth children and adults can transmit and are susceptible to SARS-CoV-2 infection. SIR did not vary by age, but further research is needed to understand age-related differences in probability of transmission from primary cases by age.

Identifiers

PMID34426817
PMCPMC8382134
OpenAlexW3195203864

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.