ReviewNature reviews. Chemistry2021
Towards the sustainable discovery and development of new antibiotics.
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Review in Nature reviews. Chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 501 papers.
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501citing papers in PubMed
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501 citing papers in PubMed.
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- Design, Synthesis and Biological Evaluation of Rhodanine-Based Hydrazide Derivatives as Antibacterial, Antifungal, and Antitubercular Agents.Antibiotics (Basel, Switzerland) · 2026Article
- Microbial Natural Products Targeting theMicroorganisms · 2026Review
- Designing the Next Generation of Antibiotics: Structure, SAR, and Strategy in Medicinal Chemistry (2000-2025).Medicinal research reviews · 2026Review
- A double-layer plate method for rapid screening of cell wall-targeting antibiotic producers using a microbial whole-cell biosensor.Applied and environmental microbiology · 2026Article
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- Oral Cavity Antibacterial Discovery Pipeline Driven by Advanced Analytical Techniques.Molecules (Basel, Switzerland) · 2026Review
- Addressing antimicrobial resistance: Current challenges, emerging strategies, and an AI-powered, community-driven approach.PNAS nexus · 2026Review
- Two Novel 1,4-Naphthoquinone Derivatives as Potent Agents Against Multidrug-Resistant Staphylococcus aureus and Pathogenic Gram-Positive Bacteria.Drug development research · 2026Article
- False Novelty in Antibacterial Natural-Product Discovery: Rediscovery, Structural Misassignment, and a Checkpoint Framework for Early Verification.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Cooperative membrane association as a mechanistic origin of synergistic antimicrobial peptide activity.RSC chemical biology · 2026Review
- Proteotoxic Stress Bioreporter Enables Mechanism-Informed Antibiotic Discovery.Journal of natural products · 2026Article
- Limits of a Glycine Betaine-Derived Xenobiotic as a Trojan Horse Antimicrobial.International journal of molecular sciences · 2026Article
- Antimicrobial Systems Based on Essential Oils Advanced by Zinc Oxide Nanoparticles.ACS pharmacology & translational science · 2026Review
- Synergistic antimicrobial nanocomposite: Protamine-loaded PVP-capped silver nanoparticles for combating multidrug-resistant infections.Asian journal of pharmaceutical sciences · 2026Article
- Thymol Chemotype Thymus vulgaris L. Hydrolate: Volatile Chemical Fraction Composition and Antimicrobial Activity Against Bacterial and Fungal Pathogens.Chemistry & biodiversity · 2026Article
441 more citing papers are in PubMed but not listed here.
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Authors and funding
54 authors.
Marcus MiethkeHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.
Marco PieroniFood and Drug Department, University of Parma, Parma, Italy.
Tilmann WeberThe Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0002-8260-5120
Mark BrönstrupGerman Center for Infection Research (DZIF), Braunschweig, Germany.
Peter HammannInfectious Diseases & Natural Product Research at EVOTEC, and Justus Liebig University Giessen, Giessen, Germany.
Ludovic HalbyEpigenetic Chemical Biology, Department of Structural Biology and Chemistry, Institut Pasteur, UMR n°3523, CNRS, Paris, France.
Paola B ArimondoEpigenetic Chemical Biology, Department of Structural Biology and Chemistry, Institut Pasteur, UMR n°3523, CNRS, Paris, France.
Philippe GlaserEcology and Evolution of Antibiotic Resistance Unit, Microbiology Department, Institut Pasteur, CNRS UMR3525, Paris, France.
Bertrand AigleUniversité de Lorraine, INRAE, DynAMic, Nancy, France.ORCID 0000-0001-5266-5926
Helge B BodeDepartment of Biosciences, Goethe University Frankfurt, Frankfurt, Germany.ORCID 0000-0001-6048-5909
Rui MoreiraFaculty of Pharmacy, University of Lisbon, Lisbon, Portugal.
Yanyan LiUnit MCAM, CNRS, National Museum of Natural History (MNHN), Paris, France.
Andriy LuzhetskyyPharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany.
Marnix H MedemaBioinformatics Group, Wageningen University and Research, Wageningen, Netherlands.ORCID 0000-0002-2191-2821
Jean-Luc PernodetInstitute for Integrative Biology of the Cell (I2BC) & Microbiology Department, University of Paris-Saclay, Gif-sur-Yvette, France.ORCID 0000-0002-6129-7093
Marc StadlerGerman Center for Infection Research (DZIF), Braunschweig, Germany.
José Rubén TormoFundación MEDINA, Granada, Spain.
Olga GenilloudFundación MEDINA, Granada, Spain.
Andrew W TrumanDepartment of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.ORCID 0000-0001-5453-7485
Kira J WeissmanMolecular and Structural Enzymology Group, Université de Lorraine, CNRS, IMoPA, Nancy, France.ORCID 0000-0002-3012-2960
Eriko TakanoManchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, University of Manchester, Manchester, United Kingdom.ORCID 0000-0002-6791-3256
Stefano SabatiniDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.ORCID 0000-0003-0971-3536
Evi StegmannGerman Center for Infection Research (DZIF), Braunschweig, Germany.
Heike Brötz-OesterheltGerman Center for Infection Research (DZIF), Braunschweig, Germany.
Wolfgang WohllebenGerman Center for Infection Research (DZIF), Braunschweig, Germany.
Myriam SeemannInstitute for Chemistry UMR 7177, University of Strasbourg/CNRS, ITI InnoVec, Strasbourg, France.ORCID 0000-0002-2615-1574
Martin EmptingHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.
Anna K H HirschHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.
Brigitta LoretzHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.
Claus-Michael LehrHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.
Alexander TitzHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.ORCID 0000-0001-7408-5084
Jennifer HerrmannHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.
Timo JaegerGerman Center for Infection Research (DZIF), Braunschweig, Germany.
Silke AltGerman Center for Infection Research (DZIF), Braunschweig, Germany.
Thomas HesterkampGerman Center for Infection Research (DZIF), Braunschweig, Germany.
Mathias WinterhalterLife Sciences & Chemistry, Jacobs University Bremen, Bremen, Germany.ORCID 0000-0002-1604-3318
Andrea SchieferGerman Center for Infection Research (DZIF), Braunschweig, Germany.ORCID 0000-0002-9823-2090
Kenneth PfarrGerman Center for Infection Research (DZIF), Braunschweig, Germany.ORCID 0000-0003-3096-2465
Achim HoeraufGerman Center for Infection Research (DZIF), Braunschweig, Germany.
Heather GrazBiophys Ltd., Usk, Monmouthshire, United Kingdom.
Michael GrazSchool of Law, University of Bristol, Bristol, United Kingdom.ORCID 0000-0003-0818-2614
Mika LindvallRecursion Pharmaceuticals, Salt Lake City, UT USA.
Savithri RamurthyDrug Discovery/Medicinal Chemistry, HiberCell, New York, NY USA.
Anders KarlénDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Maarten van DongenAMR Insights, Amsterdam, Netherlands.
Hrvoje PetkovicDepartment of Food Science and Technology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Andreas KellerChair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany.ORCID 0000-0002-5361-0895
Frédéric PeyraneBEAM Alliance, Paris, France.
Stefano DonadioNAICONS Srl, Milan, Italy.
Laurent FraisseDrugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.
Laura J V PiddockThe Global Antibiotic Research and Development Partnership (GARDP), Geneva, Switzerland.ORCID 0000-0003-1460-473X
Ian H GilbertDivision of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.ORCID 0000-0002-5238-1314
Heinz E MoserNovartis Institutes for BioMedical Research (NIBR), Emeryville, CA USA.ORCID 0000-0002-8013-2139
Rolf MüllerHelmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), and Department of Pharmacy, Saarland University Campus E8.1, Saarbrücken, Germany.ORCID 0000-0002-1042-5665
Funding
Biotechnology and Biological Sciences Research Council BB/M017702/1Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9790Medical Research Council MR/P007570/1
Abstract
An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.
Indexed as
Business strategy in drug developmentDrug therapy
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