Evidence map›Paper›PMID 34426753›Full record

ArticleDisease markers2021

Identification of Six Autophagy-Related-lncRNA Prognostic Biomarkers in Uveal Melanoma.

Yao Chen, Lu Chen, Jinwei Wang, Jia Tan, Sha Wang

Abstract read
In one paragraph

Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The multiple roles of autophagy in uveal melanoma and the microenvironment.Journal of cancer research and clinical oncology · 2024
    Pooled it
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  5. Identification of novel disulfidptosis-related lncRNA signatures to predict the prognosis and immune microenvironment of skin cutaneous melanoma patients.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yao ChenHunan Key Laboratory of Ophthalmology, Eye Center of Xiangya Hospital, Central South University, China.ORCID https://orcid.org/0000-0001-5460-0149
Lu ChenHunan Key Laboratory of Ophthalmology, Eye Center of Xiangya Hospital, Central South University, China.ORCID https://orcid.org/0000-0001-8380-014X
Jinwei WangHunan Key Laboratory of Ophthalmology, Eye Center of Xiangya Hospital, Central South University, China.ORCID https://orcid.org/0000-0002-1017-2901
Jia TanHunan Key Laboratory of Ophthalmology, Eye Center of Xiangya Hospital, Central South University, China.
Sha WangHunan Key Laboratory of Ophthalmology, Eye Center of Xiangya Hospital, Central South University, China.ORCID https://orcid.org/0000-0001-5568-6503

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, no autophagy-related long noncoding RNA (lncRNA) has been reported to predict the prognosis of uveal melanoma patients. Our study screened for autophagy-related lncRNAs in 80 samples downloaded from The Cancer Genome Atlas (TCGA) database through lncRNA-mRNA coexpression. We used univariate Cox to further filter the lncRNAs. Multivariate Cox regression and LASSO regression were applied to construct an autophagy-associated lncRNA predictive model and calculate the risk score. Clinical risk factors were validated using Cox regression to determine whether they were independent prognostic indicators. Functional enrichment was performed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. The model was built with six predictive autophagy-associated lncRNAs and clustered uveal melanoma patients into high- and low-risk groups. The risk score of our model was a significant independent prognostic factor (hazard ratio = 1.0;

Indexed as

Gene Regulatory NetworksAdultAgedAged, 80 and overAutophagyBiomarkers, TumorDatabases, GeneticFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMelanomaMiddle AgedPrognosisRNA, Long NoncodingBiomarkers, TumorRNA, Long Noncoding

Identifiers

PMID34426753
PMCPMC8379639

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.