ArticleFrontiers in immunology2021
Elevated Expression of MiR-17 in Microglia of Alzheimer's Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation.
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Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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46citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 3% of its field
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Non-coding RNAs and Mitochondrial Dysfunction in Alzheimer's Disease: A Systematic Review.Molecular neurobiology · 2026Pooled it
- Circulating microRNAs as diagnostic biomarkers for ischemic stroke: evidence from comprehensive analysis and real-world validation.International journal of medical sciences · 2023Pooled it
- Autophagy and selective autophagy receptors: Key players against Alzheimer's disease.Neural regeneration research · 2026Article
- Neuron-derived SPP1 instructs microglia to limit degeneration.Science advances · 2026Article
- MicroRNA and Alzheimer's disease: Diagnostic biomarkers and potential therapeutic targets.Neural regeneration research · 2026Article
- Analysis of Circulating MicroRNAs in Patients with Diabetic Foot Ulcers and Lower Limb Amputation.International journal of molecular sciences · 2026Article
- The role of MicroRNAs in Alzheimer's disease: from pathogenesis to therapeutic potential.Molecular biology reports · 2026Review
- Article
- Tau degradation in Alzheimer's disease: Mechanisms and therapeutic opportunities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review.Molecular medicine (Cambridge, Mass.) · 2025Review
- Microglia programmed cell death in neurodegenerative diseases and CNS injury.Apoptosis : an international journal on programmed cell death · 2025Review
- Drugs repurposing in the experimental models of Alzheimer's disease.Inflammopharmacology · 2025Review
- Nutritional strategies against dementia in rural populations.Frontiers in nutrition · 2025Review
- Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer's disease.Genome medicine · 2024Article
- Insights into the Role of microRNAs as Clinical Tools for Diagnosis, Prognosis, and as Therapeutic Targets in Alzheimer's Disease.International journal of molecular sciences · 2024Review
- Elucidation of the effects of 2,5-hexandione as a metabolite ofToxicological research · 2024Article
- Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer's disease.Brain, behavior, and immunity · 2024Article
- Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice.Molecular neurodegeneration · 2024Article
- Potential Application of MicroRNAs and Some Other Molecular Biomarkers in Alzheimer's Disease.Current issues in molecular biology · 2024Review
- Autophagy in Neuroinflammation: A Focus on Epigenetic Regulation.Aging and disease · 2024Review
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 4 countries.
Shady EstfanousDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States.
Kylene P DailyDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States.
Mostafa EltobgyDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States.
Nicholas P DeemsInstitute for Behavioral Medicine Research, Ohio State University, Columbus, OH, United States.
Midhun N K AnneDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States.
Kathrin KrauseDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States.
Asmaa BadrDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States.
Kaitlin HamiltonDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States.
Cierra CaraficeDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States.
Ahmad HegaziDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States.
Arwa Abu KhweekDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States.
Hesham KelaniDepartment of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Shahid NimjeeDepartment of Neurological Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Hamdy AwadDepartment of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
Xiaoli ZhangCenter for Biostatistics, Ohio State University, Columbus, OH, United States.
Estelle Cormet-BoyakaDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Hesham HaffezBiochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Sameh SororBiochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Adel MikhailGNOME DIAGNOSTICS, Department of Scientific Research, Powell, OH, United States.
Gerard NuovoGNOME DIAGNOSTICS, Department of Scientific Research, Powell, OH, United States.
Ruth M BarrientosInstitute for Behavioral Medicine Research, Ohio State University, Columbus, OH, United States.
Mikhail A GavrilinDepartment of Internal Medicine, Ohio State University, Columbus, OH, United States.
Amal O AmerDepartment of Microbial Infection and Immunity, Infectious Diseases Institute, The Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States.
Helwan University · EGThe Ohio State University · USInstitute for Behavioral Medicine · USThe Ohio State University Wexner Medical Center · USBirzeit University · PSMax Planck Unit for the Science of Pathogens · DENeurological Surgery · US
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3MUnraveling the role of the CFTR ion channel in susceptibility to SARS-CoV-2 infection and inflammationR01AI124121 · NIAID · OHIO STATE UNIVERSITY · PI AMER, AMAL O, CORMET-BOYAKA, ESTELLE A · 2016 to 2020
$3.7MNeuroinflammation, Inflammatory Challenge, and MemoryRF1AG028271 · NIA · UNIVERSITY OF COLORADO · PI BARRIENTOS, RUTH M, MAIER, STEVEN F · 2018 to 2021
$2.4MThe role of microRNA-calibrated autophagy in innate immunity and inflammationR01HL127651 · NHLBI · OHIO STATE UNIVERSITY · PI AMER, AMAL O, CORMET-BOYAKA, ESTELLE A · 2015 to 2018
$1.5MAlzheimer’s Disease Biomarker for Diagnosis and PrognosisR21AG067755 · NIA · OHIO STATE UNIVERSITY · PI AMER, AMAL O, TARAWNEH, RAWAN · 2020 to 2021
$417kMechanistic basis of inflammation in Alzheimers DiseaseR21AG064899 · NIA · OHIO STATE UNIVERSITY · PI AMER, AMAL O · 2020 to 2021
$409kNCI NIH HHS P30 CA016058NHLBI NIH HHS R01 HL127651NIAID NIH HHS R01 AI124121NIA NIH HHS R21 AG064899NIA NIH HHS R21 AG067755NIA NIH HHS RF1 AG028271
Abstract
Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer's Disease (AD), though mechanisms underlying this dysfunction remain elusive. Here, primary microglia from adult AD (5xFAD) mice were utilized to demonstrate that 5xFAD microglia fail to degrade Aβ and express low levels of autophagy cargo receptor NBR1. In 5xFAD mouse brains, we show for the first time that AD microglia express elevated levels of microRNA cluster Mirc1/Mir17-92a, which is known to downregulate autophagy proteins. By
Indexed as
ProteolysisAlzheimer DiseaseAmyloid beta-PeptidesAnimalsAutophagyFemaleGene Expression RegulationHumansMaleMiceMicrogliaMicroRNAsAmyloid beta-PeptidesMicroRNAsMIRN17 microRNA, humanMirn17 microRNA, mouseAlzheimer’s diseaseAmyloid-βautophagymicrogliamicroRNAMir17-92aNBR1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.