ArticleNature chemistry2021
Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides.
Article in Nature chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Chemoenzymatic Modification of Microcin J25 with Single-Residue Precision Provides New-to-Nature Lasso Peptides.JACS Au · 2026Article
- Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026Review
- Self-Assembly of Peptides and Biomolecular Systems Into Functional Nanomaterials.Journal of peptide science : an official publication of the European Peptide Society · 2026Review
- Advances in Strategies for Colloidal Self-Assembly.Chemical reviews · 2026Review
- Repositioning the Leader Peptide in Graspetide Biosynthesis.Journal of the American Chemical Society · 2026Article
- Cooperative reversible assembly in triply interlocked AlChemical science · 2025Article
- Expanding the Chemical Space of Mechanically Interlocked Peptides (MIPs) via Rational Design and Metabolite Profiling.JACS Au · 2025Article
- Crown Ether-Peptide Rotaxanes.Angewandte Chemie (International ed. in English) · 2025Article
- Embracing Complexity: Peptides as Tunable Scaffolds in the Construction of Discrete Supramolecular Systems.Angewandte Chemie (International ed. in English) · 2025Review
- Effective RNA Complexation by [2]Catenanes Confers Enhanced Resistance to Enzymatic Degradation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Emerging mechanically interlocked cages.Nature reviews. Chemistry · 2025Review
- LassoPred: a tool to predict the 3D structure of lasso peptides.Nature communications · 2025Article
- Chirality Effects in Peptide-Based Dynamic Combinatorial Chemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Stereoselective construction of coconformational mechanically helical and topologically chiral [2]catenanes induced by point chirality.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- In silico design of foldable lasso peptides.Biophysical journal · 2025Article
- How nature ties peptide knots.Nature chemical biology · 2025Article
- Stimuli-responsive mechanically interlocked polymer wrinkles.Nature communications · 2024Article
- The End of the Beginning of Mechanical Stereochemistry.Accounts of chemical research · 2024Article
- Facial Selectivity in Mechanical Bond Formation: Axially Chiral Enantiomers and Geometric Isomers from a Simple Prochiral Macrocycle.Journal of the American Chemical Society · 2024Article
- Stretchable poly[2]rotaxane elastomers.Fundamental research · 2024Article
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Abstract
Mechanically interlocked molecules (MIMs), such as rotaxanes and catenanes, have captured the attention of chemists both from a synthetic perspective and because of their role as simple prototypes of molecular machines. Although examples exist in nature, most synthetic MIMs are made from artificial building blocks and assembled in organic solvents. The synthesis of MIMs from natural biomolecules remains highly challenging. Here, we report on a synthesis strategy for interlocked molecules solely made from peptides, that is, mechanically interlocked peptides (MIPs). Fully peptidic, cysteine-decorated building blocks were self-assembled in water to generate disulfide-bonded dynamic combinatorial libraries consisting of multiple different rotaxanes, catenanes and daisy chains as well as more exotic structures. Detailed NMR spectroscopy and mass spectrometry characterization of a [2]catenane comprising two peptide macrocycles revealed that this structure has rich conformational dynamics reminiscent of protein folding. Thus, MIPs can serve as a bridge between fully synthetic MIMs and those found in nature.
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