ArticleScientific reports2021
Microendoscopic calcium imaging of the primary visual cortex of behaving macaques.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Microendoscopic calcium imaging in motor cortices of macaques during rest and movement.iScience · 2025Article
- Fast neural population dynamics in primate V1 captured by a genetically-encoded voltage indicator.Research square · 2025Article
- Role of Neural Circuits in Cognitive Impairment.Neurochemical research · 2024Review
- Genetic Approaches for Neural Circuits Dissection in Non-human Primates.Neuroscience bulletin · 2023Review
- Intravenous functional gene transfer throughout the brain of non-human primates using AAV.Research square · 2023Article
- Current analysis of hypoxic-ischemic encephalopathy research issues and future treatment modalities.Frontiers in neuroscience · 2023Review
- Dissecting the Prefrontal Network With Pathway-Selective Manipulation in the Macaque Brain-A Review.Frontiers in neuroscience · 2022Review
- An implanted lennula approach to measure neural CaImaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
9 authors.
Funding
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Abstract
In vivo calcium imaging with genetically encoded indicators has recently been applied to macaque brains to monitor neural activities from a large population of cells simultaneously. Microendoscopic calcium imaging combined with implantable gradient index lenses captures neural activities from deep brain areas with a compact and convenient setup; however, this has been limited to rodents and marmosets. Here, we developed miniature fluorescent microscopy to image neural activities from the primary visual cortex of behaving macaques. We found tens of clear fluorescent signals from three of the six brain hemispheres. A subset of these neurons showed clear retinotopy and orientation tuning. Moreover, we successfully decoded the stimulus orientation and tracked the cells across days. These results indicate that microendoscopic calcium imaging is feasible and reasonable for investigating neural circuits in the macaque brain by monitoring fluorescent signals from a large number of neurons.
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Registered trials
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