ArticleNature communications2021
The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52citing papers in PubMed
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52 citing papers in PubMed, 79 citations in OpenAlex.
- Alcohol abstinence precipitates alcohol seeking and aversion-resistant intake in association with increased BNST activity.Molecular psychiatry · 2026Article
- Corticotropin-releasing hormone neurons in the bed nucleus of the stria terminalis control wakefulness in physiological and stressful conditions in mice.Molecular psychiatry · 2026Article
- Regulation of amygdala and dopamine system in naïve and chronic alcohol states.Alcohol (Fayetteville, N.Y.) · 2026Article
- CRFR2 in paraventricular thalamus (PVT) mediates heat-induced anxiety in male mice.Cell & bioscience · 2026Article
- The S1-insula Circuit Differentially Modulates Alcohol Drinking and Aversive Behavior in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Sex differences in compulsive alcohol drinking phenotypes: implications for decision-making and social behavior in a preclinical model.Psychopharmacology · 2026Article
- Central medial and paraventricular thalamic afferents to the orbitofrontal cortex have differential effects on reversal learning.Neurobiology of stress · 2026Article
- Activity of Corticotropin-Releasing Factor Neurons in the Bed Nucleus of the Stria Terminalis Reduces Anxiety-Potentiated Startle in Female Rats in an Estrous Phase-Dependent Manner.Biological psychiatry · 2026Article
- Sex-Specific Effects of Hypocretin Receptor Signaling in Corticotropin-Releasing Factor Neurons on Alcohol Drinking, Anxiety, and Extended Amygdala Neuronal Excitability.Biological psychiatry global open science · 2026Article
- The Role of the Posterior Paraventricular Nucleus of the Thalamus in Food Deprivation-Induced Heroin-Seeking Relapse, in Male and Female Rats.Addiction biology · 2026Article
- Article
- Disentangling the effects of corticotrophin releasing factor and GABA release from the bed nucleus of the stria terminalis on ethanol self-administration in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Epidemiology and clinical features of alcoholic liver disease in Hainan Province, China.World journal of hepatology · 2025Article
- Genotype-dependent functional role of the anterior and posterior paraventricular thalamus in pavlovian conditioned approach.Psychopharmacology · 2025Article
- Regulation of PVT-CeA Circuit in Deoxynivalenol-Induced Anorexia and Aversive-Like Emotions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Animal Models of Excessive Alcohol Consumption in Rodents.Current topics in behavioral neurosciences · 2025Review
- Corticotropin-Releasing Factor Modulates Binge-Like Ethanol Drinking in a Sex-Dependent Manner: Impact of Amygdala Deletion and Inhibition of a Central Amygdala to Lateral Hypothalamus Circuit.Biological psychiatry global open science · 2025Article
- Elevated GABAergic neurotransmission prevents chronic intermittent ethanol induced hyperexcitability of intrinsic and extrinsic inputs to the ventral subiculum of female rats.Neurobiology of stress · 2025Article
- Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle.Current topics in behavioral neurosciences · 2025Review
- Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice.Nature communications · 2024Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Olivia B LevineGraduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA.ORCID 0000-0003-1315-8360
Mary Jane SkellyDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
John D MillerDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jean K Rivera-IrizarryGraduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Sydney A RowsonDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jeffrey F DiBertoDepartment of Pharmacology, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Jennifer A RinkerDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Todd E ThieleDepartment of Psychology and Neuroscience, University of North Carolina, Chapel Hill, NC, USA.
Thomas L KashDepartment of Pharmacology, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0002-4747-4495
Kristen E PleilGraduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA. krp2013@med.cornell.edu.ORCID 0000-0001-6300-9414
Cornell University · USUniversity of North Carolina at Chapel Hill · USIona College · USMedical University of South Carolina · US
Funding
UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Clyde W Hodge · 2003 to 2026
$46.3MProbing Ethanol Induced Acceleration of Hindbrain and Amygdalar Pathology in an Alzheimer’s Disease ModelU01AA020911 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash, Zoe Anastasia McElligott · 2012 to 2026
$5.8MThe Role of Serotonin in Alcohol-Withdrawal Induced AnxietyR01AA019454 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash · 2010 to 2026
$5.6MThe role of rapid estrogen signaling in alcohol drinking behaviorR01AA027645 · NIAAA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Kristen Elizabeth Pleil · 2019 to 2026
$4.1MNeuropeptide Y: Role in Ethanol Intake and SensitivityR37AA013573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TODD Eric THIELE · 2019 to 2026
$3.0MGenetic and Environmental Influences on AddictionT32DA039080 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Teresa A Milner · 2017 to 2026
$1.4MThe role of excitatory inputs to BNST CRF neurons in alcohol drinking behaviorR00AA023559 · NIAAA · WEILL MEDICAL COLL OF CORNELL UNIV · PI PLEIL, KRISTEN ELIZABETH · 2017 to 2019
$887kThe role of excitatory inputs to BNST CRF neurons in alcohol drinking behaviorK99AA023559 · NIAAA · WEILL MEDICAL COLL OF CORNELL UNIV · PI PLEIL, KRISTEN ELIZABETH · 2015 to 2016
$228kImpact of Adolescent Alcohol on Development of the Prefrontal CortexF32AA025530 · NIAAA · WEILL MEDICAL COLL OF CORNELL UNIV · PI SKELLY, MARY JANE · 2016 to 2018
$105kNIAAA NIH HHS F32 AA025530NIAAA NIH HHS K99 AA023559NIAAA NIH HHS P60 AA011605NIAAA NIH HHS R00 AA023559NIAAA NIH HHS R01 AA019454NIAAA NIH HHS R01 AA027645NIAAA NIH HHS R37 AA013573NIAAA NIH HHS U01 AA020911NIDA NIH HHS T32 DA039080
Abstract
Bed nucleus of the stria terminalis (BNST) neurons that synthesize corticotropin-releasing factor (CRF) drive binge alcohol drinking and anxiety. Here, we found that female C57BL/6J mice binge drink more than males and have greater basal BNST
Indexed as
Avoidance LearningAlcohol DrinkingAnimalsAnxietyBehavior, AnimalCorticotropin-Releasing HormoneExcitatory Postsynaptic PotentialsFemaleGlutamic AcidInhibitory Postsynaptic PotentialsIntegrasesLimbic SystemMaleMiceMice, Inbred C57BLNeuronsCorticotropin-Releasing HormoneCre recombinaseGlutamic AcidIntegrases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.