Evidence map›Paper›PMID 34426528›Full record

ArticleOpen heart2021

Validation of the Intermountain Risk Score and Get with the Guidelines-Heart Failure Score in predicting mortality.

Erik K Engelsgjerd, Catherine P Benziger, Benjamin D Horne

Open access · goldAbstract readComparative StudyValidation Study
In one paragraph

Article in Open heart, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Intermittent fasting and changes in clinical risk scores: Secondary analysis of a randomized controlled trial.International journal of cardiology. Cardiovascular risk and prevention · 2023
    Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Erik K EngelsgjerdDepartment of Medicine, Des Moines University, Des Moines, Iowa, USA.
Catherine P BenzigerHeart and Vascular Center, Essentia Health, Duluth, Minnesota, USA.
Benjamin D HorneIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA benjamin.horne@imail.org.ORCID 0000-0002-2656-0263
Des Moines University · USEssentia Health · USIntermountain Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe Intermountain Risk Score (IMRS) was evaluated for validation as a mortality predictor and compared with the American Heart Association's Get With The Guidelines-Heart Failure (GWTG-HF) risk score in a rural heart failure (HF) population.

backgroundIMRS predicts mortality in general populations using common, inexpensive laboratory tests, patient age and sex, but requires validation in patients with HF.

methodsIndividuals were selected from the GWTG-HF registry at Essentia Health. This included consecutive HF inpatients age ≥18 years admitted July 2017-June 2019. IMRS was calculated using sex-specific weightings of the complete blood count, basic metabolic profile, and age.

resultsA total of 703 individuals (mean age: 74.12, 44.38% female) were studied. The 30-day IMRS predicted 30-day mortality for both sexes (females n=312: OR=1.19 (95% CI 1.08 to 1.32) per +1, p<0.001; males n=391: OR=1.23 (CI 1.12 to 1.36) per +1, p<0.001). The GWTG-HF risk score (only available in n=300, 42.7%) was independent of IMRS for 30-day mortality (OR=1.11 (CI 1.06 to 1.16) per +1, p<0.001). Using thresholds in bivariate modelling, IMRS (high vs low risk, OR=8.25 (CI 2.19 to 31.09), p=0.002) and the GWTG-HF score (tertile 3 vs 1: OR=2.18 (CI 0.84 to 5.68), p=0.11) independently predicted mortality. In multivariable analyses including covariables, IMRS (high vs low risk: OR=6.69 (CI 1.75 to 25.60), p=0.005) and the GWTG-HF score (tertile 3 vs 1: OR=2.62 (CI 0.96 to 7.12), p=0.06) remained predictors of mortality. Results were similar for 1-year mortality.

conclusionsThe IMRS and GWTG-HF scores predicted mortality of patients with HF in a large rural healthcare system. Future study of these scores as initial clinical risk estimators for evaluating their utility in improving patient health outcomes and increasing cost effectiveness is warranted.

Indexed as

Guidelines as TopicRegistriesAgedAge FactorsCause of DeathFemaleHeart FailureHospital MortalityHumansMalePredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsSurvival Ratebiomarkerscardiomyopathydilatedheart failurequality of health care

Identifiers

PMID34426528
PMCPMC8383865
OpenAlexW3194075763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.