ArticleProceedings of the National Academy of Sciences of the United States of America2021
The genetic structure of the Turkish population reveals high levels of variation and admixture.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 68 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
What it found
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
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- Extending genome-wide association studies to admixed cohorts with high degrees of relatedness.Nature genetics · 2026Article
- AAVC: An automated framework for high-accuracy ACMG-based variant classification.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
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- Genotype-dependent metabolic and inflammatory regulation at the ANRIL locus in human primary macrophages.Molecular genetics and genomics : MGG · 2026Article
- A Multi-Locus and Machine Learning-Based Assessment of SNCA Variants in Alzheimer's Disease.International journal of molecular sciences · 2026Article
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- Inherited burden for disease predisposition in diverse populations.NPJ genomic medicine · 2026Article
- Variant reclassification in cancer susceptibility genes and an updated variant spectrum of Turkish breast and colorectal cancer patients.Human genomics · 2026Article
- Targeting Hypercalciuria in SLC34A1-Related Disorders: Impact of Oral Phosphate Therapy and Novel Genetic Insights in Pediatric Case Series.Calcified tissue international · 2026Article
- Clinical Characteristics and Genetic Factors in Retinitis Pigmentosa: A Retrospective Analysis of a Turkish Patient Cohort.Medical sciences (Basel, Switzerland) · 2026Article
- GenRiskPro: A Comprehensive Whole-Genome Sequencing Analysis Platform for Clinical and Wellness Applications.Computational and structural biotechnology journal · 2026Article
- High-quality Population-specific Haplotype-resolved Reference Panel in the Genomic and Pangenomic Eras.Genomics, proteomics & bioinformatics · 2025Review
- Evaluation of the Relationship Between Neurologic Manifestations and Genetic Mutations in Wilson's Disease with Next-Generation Sequencing.Diagnostics (Basel, Switzerland) · 2025Article
- Genomic landscape of the Great Steppe: Genetic variants in healthy Kazakh individuals.Scientific data · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 9 institutions in 5 countries.
M Ece KarsDepartment of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey.ORCID 0000-0001-5922-5608
A Nazlı BaşakSuna and Inan Kıraç Foundation, Neurodegeneration Research Laboratory, Research Center for Translational Medicine, Koç University School of Medicine, 34450 Istanbul, Turkey.ORCID 0000-0001-6977-2517
O Emre OnatDepartment of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey.ORCID 0000-0002-7105-1572
Kaya BilguvarDepartment of Genetics, Yale Center for Genome Analysis, Yale University School of Medicine, New Haven, CT 06510.
Jungmin ChoiDepartment of Genetics, Yale Center for Genome Analysis, Yale University School of Medicine, New Haven, CT 06510.
Yuval ItanCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Caner ÇağlarLaboratory of Molecular Genetics, Rockefeller University, New York, NY 10065.ORCID 0000-0002-5857-757X
Robin PalvadeauSuna and Inan Kıraç Foundation, Neurodegeneration Research Laboratory, Research Center for Translational Medicine, Koç University School of Medicine, 34450 Istanbul, Turkey.
Jean-Laurent CasanovaSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065.ORCID 0000-0002-7782-4169
David N CooperInstitute of Medical Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0002-8943-8484
Peter D StensonInstitute of Medical Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.
Alper YavuzDepartment of Surgery, Keçiören Training and Research Hospital, 06000 Ankara, Turkey.
Hakan BuluşKeçiören Training and Research Hospital, Department of Surgery, University of Health Sciences, 06000 Ankara, Turkey.
Murat GünelDepartment of Genetics, Yale Center for Genome Analysis, Yale University School of Medicine, New Haven, CT 06510.
Jeffrey M FriedmanLaboratory of Molecular Genetics, Rockefeller University, New York, NY 10065.ORCID 0000-0003-2152-0868
Tayfun ÖzçelikDepartment of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey; tozcelik@bilkent.edu.tr.
Bilkent University · TRCardiff University · GBKoç University · TRRockefeller University · USYale University · USIcahn School of Medicine at Mount Sinai · USInserm · FRKorea University · KRSağlık Bilimleri Üniversitesi · TR
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MDeveloping, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MRegulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8MYale Center for Mendelian GenomicsUM1HG006504 · NHGRI · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, GUNEL, MURAT · 2016 to 2020
$14.8MMonogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19R01AI088364 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Shen-Ying Zhang · 2010 to 2026
$8.7MNHGRI Genome Sequencing Program Coordinating CenterU24HG008956 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2016 to 2020
$4.9MGenome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasisR01AI127564 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova · 2017 to 2026
$4.8MGenome-Wide Dissection of Mendelian Susceptibility to Mycobacterial DiseaseR37AI095983 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT · 2011 to 2020
$4.6MHoward Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR001866NHGRI NIH HHS U24 HG008956NHGRI NIH HHS UM1 HG006504NIAID NIH HHS P01 AI061093NIAID NIH HHS R01 AI088364NIAID NIH HHS R01 AI127564NIAID NIH HHS R37 AI095983
Abstract
The construction of population-based variomes has contributed substantially to our understanding of the genetic basis of human inherited disease. Here, we investigated the genetic structure of Turkey from 3,362 unrelated subjects whose whole exomes (
Indexed as
AllelesConsanguinityExomeExome SequencingGene FrequencyGenetic DriftGenetics, PopulationGenetic VariationGenome, HumanGenome-Wide Association StudyGenotypeHaplotypesHuman MigrationHumansTurkeyadmixturepopulation geneticssequencingTurkish Variomevariation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.