Evidence map›Paper›PMID 34426499›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of

Juhyeon Lim, Jae Jin Lee, Sun-Kyung Lee, Seoyong Kim, Seok-Yong Eum, Hyungjin Eoh

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Isotopic tracing inVirulence · 2026
    Article
  2. Article
  3. eLife · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. TargetingACS infectious diseases · 2024
    Article
  11. Article
  12. Metabolic Rewiring ofMetabolites · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Pathogens (Basel, Switzerland) · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Juhyeon LimDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Jae Jin LeeDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0001-8317-437X
Sun-Kyung LeeDivision of Immunology and Cellular Immunology, International Tuberculosis Research Center, Changwon 51755, Republic of Korea.ORCID 0000-0002-5007-7407
Seoyong KimDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0002-0071-3954
Seok-Yong EumDivision of Immunology and Cellular Immunology, International Tuberculosis Research Center, Changwon 51755, Republic of Korea.ORCID 0000-0003-4794-3068
Hyungjin EohDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033; heoh@usc.edu.ORCID 0000-0001-8774-6400

Funding

Metabolic compensation in Mycobacterium tuberculosis for the formation of persistersR21AI139386 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EOH, HYUNGJIN · 2019 to 2020
$454k
PknG mediated tailoring Mycobacterium tuberculosis adaptive metabolism is required for the persister formationR56AI143870 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EOH, HYUNGJIN · 2019 to 2019
$413k
NIAID NIH HHS R21 AI139386NIAID NIH HHS R56 AI143870
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug ToleranceAntitubercular AgentsDrug Resistance, MicrobialHumansHypoxiaMycobacterium tuberculosisPhosphoenolpyruvateTuberculosisAntitubercular AgentsPhosphoenolpyruvatedrug tolerancemetabolic remodelingphosphoenolpyruvatesynthetic lethalitytuberculosis

Identifiers

PMID34426499
PMCPMC8536378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.