Evidence map›Paper›PMID 34426479›Full record

ArticleEuropean journal of hospital pharmacy : science and practice2021

Objective evaluation of nutritional status using the prognostic nutritional index during and after chemoradiotherapy in Japanese patients with head and neck cancer: a retrospective study.

Daichiro Fujiwara, Masanobu Tsubaki, Tomoya Takeda, Makoto Miura, Shozo Nishida, Katsuhiko Sakaguchi

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Article in European journal of hospital pharmacy : science and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Daichiro FujiwaraDepartment of Pharmacy, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan d.fujiwara68@gmail.com.ORCID 0000-0001-9560-8235
Masanobu TsubakiDivision of Pharmacotherapy, School of Pharmacy, Kindai University, Higashi-Osaka, Japan.
Tomoya TakedaDivision of Pharmacotherapy, School of Pharmacy, Kindai University, Higashi-Osaka, Japan.
Makoto MiuraDepartment of Otolaryngology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan.
Shozo NishidaDivision of Pharmacotherapy, School of Pharmacy, Kindai University, Higashi-Osaka, Japan.
Katsuhiko SakaguchiDepartment of Pharmacy, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan.
Japanese Red Cross Society Wakayama Medical Center · JPKindai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe incidence of severe mucosal damage due to low nutritional status is high in patients receiving concurrent chemoradiotherapy (CCRT) for head and neck cancer. Objective assessments do not exist for discharge criteria after completion of CCRT. Although the prognostic nutritional index (PNI) is an objective indicator of postoperative outcomes in patients undergoing cancer surgery, the prognostic impact of the PNI in patients with head and neck cancer receiving CCRT is unexplored. We investigated whether the PNI could be an objective criterion for nutritional status and a discharge criterion after completion of CCRT.

methodsWe assessed the medical records of 23 patients with head and neck cancer who received triweekly cisplatin +radiotherapy (2 Gy ×35 fractions). We evaluated whether the PNI could be a useful evaluation indicator in patients with head and neck cancer receiving CCRT and determined the cut-off PNI value by receiver operating characteristic (ROC) curve analysis as a criterion for hospital discharge.

resultsThe PNI pre-treatment and post-treatment values were 51.0 and 38.0, respectively (p<0.05). The median length of hospitalisation after therapy was 5 days in patients with grades 1 and 2 and 10 days in patients with grade 3 oral and pharyngeal mucositis (p<0.05). The optimal cut-off PNI value as a criterion for hospital discharge was found to be 40.4 (grades 1 and 2 mucositis) and 38.6 (grade 3 mucositis) by the ROC analysis.

conclusionsThe PNI is a simple, objective and temporal indicator which is useful in assessing the nutritional status of patients with head and neck cancer. The PNI could be used as an objective indicator to determine the time of discharge after CCRT completion.

Indexed as

Head and Neck NeoplasmsNutrition AssessmentChemoradiotherapyHumansJapanNutritional StatusPrognosisRetrospective Studiesconcurrent chemoradiotherapyhead and neck cancermucositisnutritional statusprognostic nutritional index

Identifiers

PMID34426479
PMCPMC8403783
OpenAlexW2968751824

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