Evidence map›Paper›PMID 34425917›Full record

ArticleBioelectronic medicine2021

Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography.

Andrew Perley, Mehrdad Roustaei, Marcelo Aguilar-Rivera, David C Kunkel, Tzung K Hsiai, Todd P Coleman, Parinaz Abiri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioelectronic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew PerleyDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA.
Mehrdad RoustaeiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Marcelo Aguilar-RiveraDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA.
David C KunkelDivision of Gastroenterology, University of California, San Diego, La Jolla, CA, 92093, USA.
Tzung K HsiaiDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Todd P ColemanDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA.
Parinaz AbiriDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. pabiri@ucla.edu.ORCID http://orcid.org/0000-0002-0520-6863
University of California San Diego · USUniversity of California, Los Angeles · US

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
Molecular Biophysics Training Program at StanfordT32GM136568 · NIGMS · STANFORD UNIVERSITY · PI Zev Bryant, KERWYN C. HUANG · 2021 to 2026
$3.7M
Intravascular Deployment of a Wirelessly Powered Micro-PacerR01HL149808 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tzung K Hsiai · 2020 to 2026
$2.8M
Inverse Methods for Spatiotemporal Characterization of Gastric Electrical Activity and its Association with Upper GI Symptoms from Cutaneous Multi-electrode RecordingsR03EB031189 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COLEMAN, TODD P · 2021 to 2022
$158k
NHLBI NIH HHS HL149808NHLBI NIH HHS R01 HL149808NIBIB NIH HHS EB031189NIGMS NIH HHS GM008042NIGMS NIH HHS T32 GM136568
6 · The paper itself

Abstract

backgroundGastroparesis is a debilitating disease that is often refractory to pharmacotherapy. While gastric electrical stimulation has been studied as a potential treatment, current devices are limited by surgical complications and an incomplete understanding of the mechanism by which electrical stimulation affects physiology.

methodsA leadless inductively-powered pacemaker was implanted on the gastric serosa in an anesthetized pig. Wireless pacing was performed at transmitter-to-receiver distances up to 20 mm, frequency of 0.05 Hz, and pulse width of 400 ms. Electrogastrogram (EGG) recordings using cutaneous and serosal electrode arrays were analyzed to compute spectral and spatial statistical parameters associated with the slow wave.

resultsOur data demonstrated evident change in EGG signal patterns upon initiation of pacing. A buffer period was noted before a pattern of entrainment appeared with consistent and low variability in slow wave direction. A spectral power increase in the EGG frequency band during entrainment also suggested that pacing increased strength of the slow wave.

conclusionOur preliminary in vivo study using wireless pacing and concurrent EGG recording established the foundations for a minimally invasive approach to understand and optimize the effect of pacing on gastric motor activity as a means to treat conditions of gastric dysmotility.

Indexed as

ElectrogastrogramElectrogastrographyGastric pacemakerGastric pacingGastroparesisWireless electrical stimulationWireless pacing

Identifiers

PMID34425917
PMCPMC8383397
OpenAlexW3194980312

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.