ArticleFungal biology and biotechnology2021
Understanding and controlling filamentous growth of fungal cell factories: novel tools and opportunities for targeted morphology engineering.
Article in Fungal biology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Microbial Hydrolysates as Amino Acid Source in Cell Culture Media for Cellular Agriculture.Biotechnology and bioengineering · 2026Review
- Fungal-Based Biogenic Silver Nanoparticles: Synthesis, Mathematical Modeling and Application.Molecules (Basel, Switzerland) · 2026Article
- Vasicine-Based Synergistic Antifungal Agents against FLC-ResistantACS medicinal chemistry letters · 2026Article
- Understanding pellet population heterogeneity of Aspergillus niger in stirred tank and rocking motion bioreactors.Applied microbiology and biotechnology · 2026Article
- Co-cultivation dynamics of the filamentous microorganisms Aspergillus niger and Streptomyces coelicolor in shake flasks.Microbial cell factories · 2026Article
- Psilocybin Production With Genetically Modified Aspergillus nidulans Under Pressurized Conditions.Biotechnology and bioengineering · 2026Article
- AI-enabled fungal biomanufacturing: from genome mining to the artificial intelligence virtual cell.Mycology · 2026Review
- Submerged Fermentation ofACS omega · 2025Article
- Effects of bioreactor inoculation method on secondary metabolite production and morphological characteristics of Streptomyces rimosus in microparticle-enhanced cultivation (MPEC).Microbial cell factories · 2025Article
- Burst agitation rate promotes sustained semicontinuous cultivation of filamentous fungi in stirred tank reactors.Applied microbiology and biotechnology · 2025Article
- Exploring the Critical Environmental Optima and Biotechnological Prospects of Fungal Fruiting Bodies.Microbial biotechnology · 2025Review
- Article
- Production of Protease Inhibitor WithEngineering in life sciences · 2025Article
- Cultivation of filamentous fungi in airlift bioreactors: advantages and disadvantages.Applied microbiology and biotechnology · 2025Review
- Oxygen Consumption in Filamentous Pellets of Aspergillus niger: Microelectrode Measurements and Modeling.Biotechnology and bioengineering · 2025Article
- Promoter engineering with programmable upstream activating sequences in Aspergillus Niger cell factory.Microbial cell factories · 2025Article
- Initial pH determines the morphological characteristics and secondary metabolite production in Aspergillus terreus and Streptomyces rimosus cocultures.Archives of microbiology · 2024Article
- Advanced Fungal Biotechnologies in Accomplishing Sustainable Development Goals (SDGs): What Do We Know and What Comes Next?Journal of fungi (Basel, Switzerland) · 2024Review
- High-throughput screening carbon and nitrogen sources to promote growth and sporulation in Rhizopus arrhizus.AMB Express · 2024Article
- A Multiomics Perspective on Plant Cell Wall-Degrading Enzyme Production: Insights from the Unexploited FungusJournal of fungi (Basel, Switzerland) · 2024Article
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Authors and funding
10 authors.
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Abstract
Filamentous fungal cell factories are efficient producers of platform chemicals, proteins, enzymes and natural products. Stirred-tank bioreactors up to a scale of several hundred m³ are commonly used for their cultivation. Fungal hyphae self-assemble into various cellular macromorphologies ranging from dispersed mycelia, loose clumps, to compact pellets. Development of these macromorphologies is so far unpredictable but strongly impacts productivities of fungal bioprocesses. Depending on the strain and the desired product, the morphological forms vary, but no strain- or product-related correlations currently exist to improve process understanding of fungal production systems. However, novel genomic, genetic, metabolic, imaging and modelling tools have recently been established that will provide fundamental new insights into filamentous fungal growth and how it is balanced with product formation. In this primer, these tools will be highlighted and their revolutionary impact on rational morphology engineering and bioprocess control will be discussed.
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