ArticleGenome biology2021
Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus.
Article in Genome biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Canadian COVID-19 host genetics cohort replicates known severity associations.PLoS genetics · 2024Pooled it
- Pooled it
- Prioritizing long COVID related single nucleotide polymorphisms by mining genome-wide association studies of COVID-19 susceptibility and hospitalization.Frontiers in systems biology · 2026Article
- Genetic association of ACE2 rs2285666 (C>T) and rs2106809 (A>G) and susceptibility to SARS-CoV-2 infection among the Ghanaian population.Frontiers in genetics · 2025Article
- COVID-19 Is a Coronary Artery Disease Risk Equivalent and Exhibits a Genetic Interaction With ABO Blood Type.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- rs71327024 Associated with COVID-19 Hospitalization ReducesInternational journal of molecular sciences · 2023Article
- eQTL Catalogue 2023: New datasets, X chromosome QTLs, and improved detection and visualisation of transcript-level QTLs.PLoS genetics · 2023Article
- Single-cell genomics meets human genetics.Nature reviews. Genetics · 2023Review
- Article
- Host Genetic Factors, Comorbidities and the Risk of Severe COVID-19.Journal of epidemiology and global health · 2023Article
- Pan-Cancer Analysis of the COVID-19 Causal GeneACS omega · 2023Article
- Systematic visualisation of molecular QTLs reveals variant mechanisms at GWAS loci.bioRxiv : the preprint server for biology · 2023Article
- The race to understand immunopathology in COVID-19: Perspectives on the impact of quantitative approaches to understand within-host interactions.Immunoinformatics (Amsterdam, Netherlands) · 2023Review
- Article
- COVID-19 immunopathology: From acute diseases to chronic sequelae.Journal of medical virology · 2023Review
- Structures of ACE2-SIT1 recognized by Omicron variants of SARS-CoV-2.Cell discovery · 2022Article
- COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs.International journal of molecular sciences · 2022Review
- Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infection.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Article
- The human genetic epidemiology of COVID-19.Nature reviews. Genetics · 2022Review
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that modulate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.