ArticleBMC gastroenterology2021
Long-term prognosis after endoscopic submucosal dissection for colorectal tumors in patients aged over 80 years.
Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Colorectal cancer screening and management in the aging society: a narrative review of benefit, risk, and the biological imperative for rural and community medicine.Journal of rural medicine : JRM · 2026Article
- Outcome and Prognostic Factors of Colorectal Endoscopic Submucosal Dissection in Patients Aged Over 75 Years.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Retrospective Cohort Study on the Efficacy and Safety of Endoscopic Submucosal Dissection for Gastrointestinal Lesions: A Single-Center Experience.Middle East journal of digestive diseases · 2025Article
- Salvage Surgery After Non-Curative Endoscopic Submucosal Dissection for Early Colorectal Cancer: A Comprehensive Review.Journal of clinical medicine · 2025Review
- The Old: Is There Any Role for Screening Colonoscopy after the Age of 75? The Surgeon's Perspective.Clinics in colon and rectal surgery · 2025Review
- Clinical outcome and long‑term prognosis after endoscopic submucosal dissection for colorectal tumors in patients aged 75 years or older: a retrospective observational study.International journal of colorectal disease · 2024Observational
- Long-term prognosis after endoscopic submucosal dissection for esophageal cancer in older adult patients.BMC gastroenterology · 2024Article
- The feasibility of endoscopic resection for colorectal laterally spreading tumors.Updates in surgery · 2023Article
- Long-term outcomes after endoscopic submucosal dissection for colorectal epithelial neoplasms in patients with severe comorbidities.JGH open : an open access journal of gastroenterology and hepatology · 2023Article
- Outcomes of Endoscopic Resection for Early Gastric Cancer in Very Elderly Patients: A Nationwide Population-Based Study.Gut and liver · 2023Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Japan, endoscopic submucosal dissection (ESD) is standardized for large colorectal tumors. However, its validity in the elderly population is unclear. We aimed to evaluate the safety and efficacy of ESD for colorectal tumors in elderly patients aged over 80 years.
methodsESD was performed on 178 tumors in 165 consecutive patients aged over 80 years between December 2008 and December 2018. We retrospectively evaluated the clinicopathological characteristics and clinical outcomes of ESD. We also assessed the prognosis of 160 patients followed up for more than 12 months.
resultsThe mean patient age was 83.7 ± 3.1 years. The number of patients with comorbidities was 100 (62.5%). Among all patients, 106 (64.2%) were categorized as class 1 or 2 according to the American Society of Anesthesiologists classification of physical status (ASA-PS), and 59 (35.8%) were classified as class 3. The mean procedure time was 97.7 ± 79.3 min. The rate of histological en bloc resection was 93.8% (167/178). Delayed bleeding in 11 cases (6.2%) and perforation in 7 cases (3.9%) were treated conservatively. The 5-year survival rate was 89.9%. No deaths from primary disease (mean follow-up time: 35.3 ± 27.5 months) were observed. Overall survival rates were significantly lower in the non-curative resection group that did not undergo additional surgery than in the curative resection group (P = 0.0152) and non-curative group that underwent additional surgery (P = 0.0259). Overall survival rates were higher for ASA-PS class 1 or 2 patients than class 3 patients (P = 0.0105). Metachronous tumors (> 5 mm) developed in 9.4% of patients.
conclusionsESD for colorectal tumors in patients aged over 80 years is safe. Colorectal cancer-associated deaths were prevented although comorbidities pose a high risk of poor prognosis.
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