Evidence map›Paper›PMID 34425702›Full record

ArticlemBio2021

Insights from Clonal Expansion and HIV Persistence in Perinatal Infections.

Adit Dhummakupt, Deborah Persaud

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adit DhummakuptJohns Hopkins University, School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Baltimore, Maryland, USA.
Deborah PersaudJohns Hopkins University, School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Baltimore, Maryland, USA.
Johns Hopkins University · US

Funding

Targeting HIV reservoirs in children with HIVIS DNA and MVA-CMDR vaccinesU01AI135941 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI PALMA, PAOLO, ROBB, MERLIN L · 2018 to 2024
$6.4M
Deciphering Mechanisms of HIV Latency Reversal in Perinatal InfectionsR01AI150412 · NIAID · JOHNS HOPKINS UNIVERSITY · PI PERSAUD, DEBORAH · 2020 to 2023
$3.1M
NIAID NIH HHS R01 AI150412NIAID NIH HHS U01 AI135941
6 · The paper itself

Abstract

The latent HIV reservoir forms early in the course of infection and is maintained for life despite effective antiretroviral treatment (ART), including early treatment. Perinatal HIV infection presents a unique opportunity to limit seeding of the reservoir through early ART. However, a greater understanding of the persistence of the integrated proviruses is needed for targeting the residual proviruses that form barriers to cure. A study was performed by Bale and Katusiime et al. (M. J. Bale, M. G. Katusiime, D. Wells, X. Wu, et al., mBio 12:e00568-21, 2021, https://doi.org/10.1128/mBio.00568-21) using in-depth integration site analysis in 11 children before ART and after up to nine years of ART. They have identified early development of long-lived proviruses, although the replication competence is unknown. A small fraction of cells bearing integrated proviruses clonally expand early during infection and persist. Integration in the oncogenes

Indexed as

HIV-1HIV InfectionsCD4-Positive T-LymphocytesHumansProvirusesVirus LatencyVirus Replicationclonal expansionhuman immunodeficiency viruslatent reservoirperinatal infections

Identifiers

PMID34425702
PMCPMC8406253
OpenAlexW3193692640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.