Evidence map›Paper›PMID 34425544›Full record

ArticleClinical imaging2021

Application of deep learning to identify COVID-19 infection in posteroanterior chest X-rays.

Jenish Maharjan, Jacob Calvert, Emily Pellegrini, Abigail Green-Saxena, Jana Hoffman, Andrea McCoy, Qingqing Mao, Ritankar Das

Abstract read
In one paragraph

Article in Clinical imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jenish MaharjanDascena, Inc., Houston, TX, United States. Electronic address: jmaharjan@dascena.com.
Jacob CalvertDascena, Inc., Houston, TX, United States. Electronic address: jake@dascena.com.
Emily PellegriniDascena, Inc., Houston, TX, United States. Electronic address: emilypellegrini@dascena.com.
Abigail Green-SaxenaDascena, Inc., Houston, TX, United States. Electronic address: abigail@dascena.com.
Jana HoffmanDascena, Inc., Houston, TX, United States. Electronic address: jana@dascena.com.
Andrea McCoyCape Regional Medical Center, Cape May Court House, NJ, United States. Electronic address: amccoy@caperegional.com.
Qingqing MaoDascena, Inc., Houston, TX, United States. Electronic address: qmao@dascena.com.
Ritankar DasDascena, Inc., Houston, TX, United States. Electronic address: ritankar@dascena.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe objective of this study was to assess seven configurations of six convolutional deep neural network architectures for classification of chest X-rays (CXRs) as COVID-19 positive or negative.

methodsThe primary dataset consisted of 294 COVID-19 positive and 294 COVID-19 negative CXRs, the latter comprising roughly equally many pneumonia, emphysema, fibrosis, and healthy images. We used six common convolutional neural network architectures, VGG16, DenseNet121, DenseNet201, MobileNet, NasNetMobile and InceptionV3. We studied six models (one for each architecture) which were pre-trained on a vast repository of generic (non-CXR) images, as well as a seventh DenseNet121 model, which was pre-trained on a repository of CXR images. For each model, we replaced the output layers with custom fully connected layers for the task of binary classification of images as COVID-19 positive or negative. Performance metrics were calculated on a hold-out test set with CXRs from patients who were not included in the training/validation set.

resultsWhen pre-trained on generic images, the VGG16, DenseNet121, DenseNet201, MobileNet, NasNetMobile, and InceptionV3 architectures respectively produced hold-out test set areas under the receiver operating characteristic (AUROCs) of 0.98, 0.95, 0.97, 0.95, 0.99, and 0.96 for the COVID-19 classification of CXRs. The X-ray pre-trained DenseNet121 model, in comparison, had a test set AUROC of 0.87. DISCUSSION: Common convolutional neural network architectures with parameters pre-trained on generic images yield high-performance and well-calibrated COVID-19 CXR classification.

Indexed as

COVID-19Deep LearningHumansNeural Networks, ComputerSARS-CoV-2X-RaysClassificationCOVID-19Deep learningDiagnosisNeural networksX-rays

Identifiers

PMID34425544
PMCPMC8302887

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.