Evidence map›Paper›PMID 34425496›Full record

ArticleVirology2021

A novel lineage of polyomaviruses identified in bark scorpions.

Kara Schmidlin, Simona Kraberger, Chelsea Cook, Dale F DeNardo, Rafaela S Fontenele, Koenraad Van Doorslaer, Darren P Martin, Christopher B Buck, Arvind Varsani

Open access · greenAbstract read
In one paragraph

Article in Virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  11. Diversity and evolution of the animal virome.Nature reviews. Microbiology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Kara SchmidlinThe Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, 85287, USA; School of Life Sciences, Arizona State University, Tempe, AZ, 85287, USA.
Simona KrabergerThe Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, 85287, USA.
Chelsea CookDepartment of Biological Sciences, Marquette University, 11428 W. Clybourn St, Milwaukee, WI, 53233, USA.
Dale F DeNardoSchool of Life Sciences, Arizona State University, Tempe, AZ, 85287, USA.
Rafaela S FonteneleThe Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, 85287, USA; School of Life Sciences, Arizona State University, Tempe, AZ, 85287, USA.
Koenraad Van DoorslaerGenetics Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ, 85719, USA; School of Animal and Comparative Biomedical Sciences, The BIO5 Institute, Department of Immunobiology, Cancer Biology Graduate Interdisciplinary Program, UA Cancer Center, University of Arizona Tucson, Tucson, AZ, 85724, USA.
Darren P MartinComputational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Christopher B BuckLab of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Arvind VarsaniThe Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, 85287, USA; School of Life Sciences, Arizona State University, Tempe, AZ, 85287, USA; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, 85287, USA; Structural Biology Research Unit, Department of Clinical Laboratory Sciences, University of Cape Town, 7925, Cape Town, South Africa. Electronic address: Arvind.varsani@asu.edu.
Arizona State University · USUniversity of Cape Town · ZAMarquette University · USNational Institutes of Health · USUniversity of Arizona · US

Funding

Molecular biology of human polyomavirusesZIABC011090 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BUCK, CHRISTOPHER · 2009 to 2025
$9.3M
BKV and JCV vaccine developmentZIABC011460 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BUCK, CHRISTOPHER · 2012 to 2025
$7.8M
Intramural NIH HHS ZIA BC011090Intramural NIH HHS ZIA BC011460
6 · The paper itself

Abstract

Polyomaviruses are non-enveloped viruses with circular double-stranded DNA genomes (~4-7 kb). Initially identified in mammals, polyomaviruses have now been identified in birds and a few fish species. Although fragmentary polyomavirus-like sequences have been detected as apparent 'hitchhikers' in shotgun genomics datasets of various arthropods, the possible diversity of these viruses in invertebrates remains unclear. Scorpions are predatory arachnids that are among the oldest terrestrial animals. Using high-throughput sequencing and traditional molecular techniques we determine the genome sequences of eight novel polyomaviruses in scorpions (Centruroides sculpturatus) from the greater Phoenix area, Arizona, USA. Analysis of Centruroides transcriptomic datasets elucidated the splicing of the viral late gene array, which is more complex than that of vertebrate polyomaviruses. Phylogenetic analysis provides further evidence of co-divergence of polyomaviruses with their hosts, suggesting that at least one ancestral species of polyomaviruses was circulating amongst the primitive common ancestors of arthropods and chordates.

Indexed as

PhylogenyAnimalsGenome, ViralPolyomavirusRecombination, GeneticScorpionsArachnidaCentruroides sculpturatusCircular DNA virusPolyomaviridae

Identifiers

PMID34425496
PMCPMC8478886
OpenAlexW3195706651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.