Evidence map›Paper›PMID 34425331›Full record

ArticleParkinsonism & related disorders2021

Sleep disturbances in the speech-language variant of progressive supranuclear palsy.

Fatma Ozlem Hokelekli, Farwa Ali, Arenn F Carlos, Peter R Martin, Heather M Clark, Joseph R Duffy, Rene L Utianski, Hugo Botha, Erik K St Louis, Jennifer L Whitwell and 1 more

Open access · greenAbstract read
In one paragraph

Article in Parkinsonism & related disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Unraveling sleep dysfunction in progressive supranuclear palsy: a pilot study on the role of periodic limb movements in sleep and insomnia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  4. Article
  5. Article
  6. An Update on Apraxia of Speech.Current neurology and neuroscience reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Fatma Ozlem HokelekliDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Farwa AliDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Arenn F CarlosDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Peter R MartinDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Heather M ClarkDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Joseph R DuffyDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Rene L UtianskiDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Hugo BothaDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Erik K St LouisDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Center for Sleep Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: josephs.keith@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic · USMayo Clinic in Florida · US

Funding

Longitudinal multi-modality imaging in progressive apraxia of speech (Diversity Supplement)R01DC012519 · NIDCD · MAYO CLINIC ROCHESTER · PI Jennifer Louise Whitwell · 2013 to 2026
$7.2M
Longitudinal Multi-modal Imaging in Progressive Supranuclear Palsy SyndromesR01NS089757 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A, WHITWELL, JENNIFER LOUISE · 2015 to 2024
$5.6M
The neurobiology of two distinct types of progressive apraxia of speechR01DC014942 · NIDCD · MAYO CLINIC ROCHESTER · PI Keith A Josephs, Rene Lynn Utianski · 2017 to 2026
$4.9M
NIDCD NIH HHS R01 DC012519NIDCD NIH HHS R01 DC014942NINDS NIH HHS R01 NS089757
6 · The paper itself

Abstract

introductionProgressive supranuclear palsy (PSP) variants other than PSP-Richardson Syndrome (PSP-RS) have been recognized, including PSP with speech and language problems (PSP-SL). Given the reported sleep disruptions in PSP-RS, we investigated sleep abnormalities in PSP-SL.

methodsFour sleep-related screening questions were given to the caregivers of 90 patients with PSP-SL (59 suggestive of PSP-SL and 31 possible PSP-SL) and 71 probable PSP-RS (prob. PSP-RS) patients.

resultsAt least one sleep-related disturbance was observed in 35.6% of suggestive of PSP-SL, 38.7% of possible PSP-SL, and 67.6% of prob. PSP-RS, the most common being "unable to fall or stay asleep". Prob. PSP-RS showed higher frequency of "screaming or talking in sleep", "acting out dreams", and "unable to fall or stay asleep" compared to both PSP-SL groups, but did not differ from possible PSP-SL in "excessive daytime sleepiness".

conclusionSleep abnormalities are common in PSP-SL, but less frequent than prob.PSP-RS.

Indexed as

SleepAgedFemaleHumansMaleMiddle AgedSleep Wake DisordersSpeechSpeech DisordersSupranuclear Palsy, ProgressiveLanguageProgressive supranuclear palsyPSP-RSPSP-SLSpeech

Identifiers

PMID34425331
PMCPMC8585691
OpenAlexW3193567761

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.