Evidence map›Paper›PMID 34425314›Full record

ArticleJournal of affective disorders2021

Age effects on clinical and neurocognitive risk factors for suicide attempt in depression - Findings from the AFSP lifespan study.

Morgan Buerke, Hanga Galfalvy, John G Keilp, Arielle H Sheftall, Ainsley K Burke, Jeffrey A Bridge, J John Mann, Katalin Szanto

Open access · greenAbstract read
In one paragraph

Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Is Late-Onset Suicidal Behavior a Distinct Subtype?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. The Relationship between Depressive Symptoms, Rumination, and Suicide Ideation in Patients with Depression.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Morgan BuerkeUniversity of Pittsburgh School of Medicine, Department of Psychiatry, 100 N Bellefield Avenue, Floor 7, Pittsburgh, PA 15213, United States. Electronic address: mbuerke@kent.edu.
Hanga GalfalvyColumbia University College of Physicians and Surgeons, Department of Psychiatry, New York, NY, United States; New York State Psychiatric Institute, Department of Molecular Imaging and Neuropathology, New York, NY, United States.
John G KeilpColumbia University College of Physicians and Surgeons, Department of Psychiatry, New York, NY, United States; New York State Psychiatric Institute, Department of Molecular Imaging and Neuropathology, New York, NY, United States.
Arielle H SheftallOhio State University College of Medicine, Departments of Pediatrics and Psychiatry & Behavioral Health, Columbus, OH, United States.
Ainsley K BurkeColumbia University College of Physicians and Surgeons, Department of Psychiatry, New York, NY, United States; New York State Psychiatric Institute, Department of Molecular Imaging and Neuropathology, New York, NY, United States.
Jeffrey A BridgeOhio State University College of Medicine, Departments of Pediatrics and Psychiatry & Behavioral Health, Columbus, OH, United States.
J John MannColumbia University College of Physicians and Surgeons, Department of Psychiatry, New York, NY, United States; New York State Psychiatric Institute, Department of Molecular Imaging and Neuropathology, New York, NY, United States.
Katalin SzantoUniversity of Pittsburgh School of Medicine, Department of Psychiatry, 100 N Bellefield Avenue, Floor 7, Pittsburgh, PA 15213, United States.
New York Psychoanalytic Society and Institute · USThe Ohio State University · USUniversity of Pittsburgh · US

Funding

Suicidal Behavior: Aggression Subtypes, Childhood Adversity and Stress ResponseP50MH090964 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MANN, JOSEPH JOHN · 2013 to 2022
$23.6M
Short Term Variability in Affect and Rest Activity Rhythms in Long Term Chronic and Highly Variable Suicidal Ideation in Depressed Older AdultsR01MH085651 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANGA CSILLA GALFALVY, Swathi Gujral · 2010 to 2026
$9.6M
NIMH NIH HHS P50 MH090964NIMH NIH HHS R01 MH085651
6 · The paper itself

Abstract

backgroundStudies of risk factors for suicidal behavior are typically restricted to narrow age ranges, making it difficult to determine if they have the same relevance or potency across the full adult lifespan.

methodsThis study examined selected clinical and neurocognitive risk factors for suicidal behavior - borderline personality traits, aggression, depressive rumination, memory performance, and language fluency- in a multi-site sample (N = 309, ages 16-80) of depressed patients with a recent (last 5 years) suicide attempt or no history of attempt, and demographically similar non-psychiatric controls. We examined cross-sectional age and attempter/non-attempter differences on these risk factors, and whether certain risk factors were more prominent discriminators of past suicide attempt earlier or later in the lifespan. Correlations with age were computed, and logistic regression was used to classify attempter status based on each risk factor and its interaction with age.

resultsNearly all risk factors were negatively correlated with age. Borderline traits, aggression, memory, and category fluency each predicted attempter status (p < 0.05), but these effects were not different across ages. In contrast, the association between rumination and suicide attempt status differed across the lifespan, becoming a stronger discriminator of past suicidal behavior at older ages. LIMITATIONS: The cross-sectional design limits our developmental findings.

conclusionsDespite age-related changes in symptom severity or neurocognitive performance, key risk factors for suicidal behavior previously identified in studies with more restricted age-ranges are salient throughout the adult lifespan. In contrast, depressive rumination may be particularly salient in later life.

Indexed as

DepressionSuicide, AttemptedAdolescentAdultAgedAged, 80 and overCross-Sectional StudiesHumansLongevityMiddle AgedPsychiatric Status Rating ScalesRisk FactorsYoung AdultAge effectsAggressionBorderline personalityDepressive ruminationNeurocognitive deficitsSuicidal behavior

Identifiers

PMID34425314
PMCPMC8551053
OpenAlexW3193791967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.