ReviewThe journal of pain2022
Dorsal Root Ganglion Stimulation for Chronic Pain: Hypothesized Mechanisms of Action.
Review in The journal of pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Low-intensity focused ultrasound of the spine in the treatment of chronic pain and movement disorder: a scoping review.Frontiers in pain research (Lausanne, Switzerland) · 2025Pooled it
- Neuromodulation for Pain and Fatigue in Hereditary and Acquired Neuromuscular Conditions: A Narrative Review.Current pain and headache reports · 2026Review
- Peripheral nerve stimulation targeting the trochanteric branch of the femoral nerve for refractory greater trochanteric pain syndrome followed by dorsal root ganglion stimulation: A case report and mechanistic perspective.Interventional pain medicine · 2026Article
- A computational analysis of biophysical and geometric constraints refutes existing hypotheses of cross-excitation in dorsal root ganglia.Scientific reports · 2026Article
- Efficacy of a Novel Ultrasound-Guided C8 Dorsal Root Ganglion Puncture Approach and Radiofrequency Treatment for Postherpetic Neuralgia.Journal of pain research · 2026Article
- A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain.JOR spine · 2025Review
- Review
- Article
- CaMKIIα-NpHR-Mediated Optogenetic Inhibition of DRG Glutamatergic Neurons by Flexible Optic Fiber Alleviates Chronic Neuropathic Pain.Neuromolecular medicine · 2025Article
- Dermatologic manifestations of complex regional pain syndrome improved after dorsal root ganglion stimulation.Surgical neurology international · 2025Article
- Dorsal root ganglion stimulation provides functional improvement from debilitating abdominal pain in Crohn's disease: A 12-month follow-up.Interventional pain medicine · 2024Article
- A brief review of complex regional pain syndrome and current management.Annals of medicine · 2024Review
- Functional Role of Piezo1 in the Human Eosinophil Cell Line AML14.3D10: Implications for the Immune and Sensory Nervous Systems.Biomolecules · 2024Article
- Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024Review
- Dorsal Root Ganglion Stimulation for the Management of Inflammatory Bowel Disease: A Case Report.A&A practice · 2024Article
- Computational modeling of dorsal root ganglion stimulation using an Injectrode.Journal of neural engineering · 2024Article
- Mechanisms of Action of Dorsal Root Ganglion Stimulation.International journal of molecular sciences · 2024Review
- Advanced neuroprosthetic electrode design optimized by electromagnetic finite element simulation: innovations and applications.Frontiers in bioengineering and biotechnology · 2024Review
- Current Neurostimulation Therapies for Chronic Pain Conditions.Current pain and headache reports · 2023Review
- Profile of dorsal root ganglion neurons: study of oxytocin expression.Molecular brain · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Dorsal root ganglion stimulation (DRGS) is a neuromodulation therapy for chronic pain that is refractory to conventional medical management. Currently, the mechanisms of action of DRGS-induced pain relief are unknown, precluding both our understanding of why DRGS fails to provide pain relief to some patients and the design of neurostimulation technologies that directly target these mechanisms to maximize pain relief in all patients. Due to the heterogeneity of sensory neurons in the dorsal root ganglion (DRG), the analgesic mechanisms could be attributed to the modulation of one or many cell types within the DRG and the numerous brain regions that process sensory information. Here, we summarize the leading hypotheses of the mechanisms of DRGS-induced analgesia, and propose areas of future study that will be vital to improving the clinical implementation of DRGS. PERSPECTIVE: This article synthesizes the evidence supporting the current hypotheses of the mechanisms of action of DRGS for chronic pain and suggests avenues for future interdisciplinary research which will be critical to fully elucidate the analgesic mechanisms of the therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.