ArticleBehavioural brain research2022
Insular cortex modulates social avoidance of sick rats.
Article in Behavioural brain research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Oxytocin modulation of the insular cortex: implications for social cognition and neurodevelopmental disorders.Frontiers in neural circuits · 2026Review
- Insular input to the prelimbic cortex underlies social affective behavior in rats.bioRxiv : the preprint server for biology · 2025Article
- Pathogen infection induces sickness behaviors through neuromodulators linked to stress and satiety in C. elegans.Nature communications · 2025Article
- Neural cell-types and circuits linking thermoregulation and social behavior.Neuroscience and biobehavioral reviews · 2024Review
- Neurobiology of Pathogen Avoidance and Mate Choice: Current and Future Directions.Animals : an open access journal from MDPI · 2024Review
- Serotonin modulates social responses to stressed conspecifics via insular 5-HTNeuropharmacology · 2023Article
- Social affective behaviors among female rats involve the basolateral amygdala and insular cortex.bioRxiv : the preprint server for biology · 2023Article
- Social affective behaviors among female rats involve the basolateral amygdala and insular cortex.PloS one · 2023Article
- The basolateral amygdala to posterior insular cortex tract is necessary for social interaction with stressed juvenile rats.Behavioural brain research · 2022Article
- The role of oxytocin in shaping complex social behaviours: possible interactions with other neuromodulators.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Insular cortex corticotropin-releasing factor integrates stress signaling with social affective behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Social factors and the neurobiology of pathogen avoidance.Biology letters · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Avoidance of sick individuals is vital to the preservation of one's health and preventing transmission of communicable diseases. To do this successfully, one must identify social cues for sickness, which include sickness behaviors and chemosignals, and use this information to orchestrate social interactions. While many social species are highly capable with this process, the neural mechanisms that provide for social responses to sick individuals are only partially understood. To this end, we used a task in which experimental rats were allowed to investigate two conspecifics, one healthy and one sick. To imitate sickness, one conspecific received the viral mimic Polyinosinic:polycytidylic acid (Poly I:C) and the other saline. In a 5-minute social preference test, experimental male and female adult rats avoided Poly I:C treated adult conspecifics but did not adjust social interaction in response to Poly I:C treated juvenile conspecifics. Seeking a neural locus of this behavior, we inhibited the insular cortex, a region necessary for social behaviors directed toward conspecifics in distress. Insular cortex inactivation via administration of the GABA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.