Trial reportResuscitation2021
Outcomes of delivery room resuscitation of bradycardic preterm infants: A retrospective cohort study of randomised trials of high vs low initial oxygen concentration and an individual patient data analysis.
Trial report in Resuscitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- [Guideline for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal resuscitation (2025)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Guideline
- European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update.Neonatology · 2023Guideline
- Future perspectives of heart rate and oxygenation monitoring in the neonatal intensive care unit - a narrative review.Journal of clinical monitoring and computing · 2025Review
- The Utility of Umbilical Cord Pulse Oximetry-A Translational Study with Four Minutes of Deferred Cord Clamping Using an Asphyxiated Preterm Ovine Model.Children (Basel, Switzerland) · 2025Article
- Association between 5-minute oxygen saturation and neonatal death and intraventricular hemorrhage among extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Postnatal hypoxic preconditioning attenuates lung damage from hyperoxia in newborn mice.Pediatric research · 2025Article
- Addressing the Humans in the Delivery Room-Optimising Neonatal Monitoring and Decision-Making in Transition.Children (Basel, Switzerland) · 2025Review
- Oxygenation associated with cord management strategies among preterm infants <32 weeks gestation during the transition period.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Fetal to neonatal transition: what additional information can be provided by cerebral near infrared spectroscopy?Pediatric research · 2024Review
- To intubate or not to intubate, is that the question?Pediatric research · 2024Article
- Article
- Oxygen in the neonatal ICU: a complicated history and where are we now?Frontiers in pediatrics · 2024Review
- Video-Recorded Airway Suctioning of Clear and Meconium-Stained Amniotic Fluid and Associated Short-Term Outcomes in Moderately and Severely Depressed Preterm and Term Infants.Children (Basel, Switzerland) · 2023Article
- Significance of Neonatal Heart Rate in the Delivery Room-A Review.Children (Basel, Switzerland) · 2023Review
- Initial Use of 100% but Not 60% or 30% Oxygen Achieved a Target Heart Rate of 100 bpm and Preductal Saturations of 80% Faster in a Bradycardic Preterm Model.Children (Basel, Switzerland) · 2022Article
- Physiology of neonatal resuscitation: Giant strides with small breaths.Seminars in perinatology · 2022Review
- Placental transfusion during neonatal resuscitation in an asphyxiated preterm model.Pediatric research · 2022Article
- Perinatal risk factors for mortality in very preterm infants-A nationwide, population-based discriminant analysis.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Ventilation-Induced Lung Injury (VILI) in Neonates: Evidence-Based Concepts and Lung-Protective Strategies.Journal of clinical medicine · 2022Review
- Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends.Antioxidants (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 10 institutions in 6 countries.
Funding
Abstract
objectiveTo determine whether hospital mortality (primary outcome) is associated with duration of bradycardia without chest compressions during delivery room (DR) resuscitation in a retrospective cohort study of randomized controlled trials (RCTs) in preterm infants assigned low versus high initial oxygen concentration.
methodsMedline and EMBASE were searched from 01/01/1990 to 12/01/2020. RCTs of low vs high initial oxygen concentration which recorded serial heart rate (HR) and oxygen saturation (SpO
resultsData were collected from 720 infants in 8 RCTs. Neonates with PB had higher odds of hospital death before [OR 3.8 (95% CI 1.5, 9.3)] and after [OR 1.7 (1.2, 2.5)] adjusting for potential confounders. Bradycardia occurred in 58% infants, while 38% had PB. Infants with bradycardia were more premature and had lower birth weights. The incidence of bradycardia in infants resuscitated with low (≤30%) and high (≥60%) oxygen was similar. Neonates with both, PB and SpO
conclusionIn preterm infants who did not receive chest compressions in the DR, prolonged bradycardia is associated with hospital mortality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.