Evidence map›Paper›PMID 34425031›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Mechanisms linking hypoxia to phosphorylation of insulin-like growth factor binding protein-1 in baboon fetuses with intrauterine growth restriction and in cell culture.

Jenica Kakadia, Kyle Biggar, Bhawani Jain, Allan W Chen, Karen Nygard, Cun Li, Peter W Nathanielsz, Thomas Jansson, Madhulika B Gupta

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 6 citations in OpenAlex.

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  9. Epigenetic Modifications at the Center of the Barker Hypothesis and Their Transgenerational Implications.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jenica KakadiaDepartment of Biochemistry, University of Western Ontario, London, ON, Canada.
Kyle BiggarInstitute of Biochemistry, Carleton University, Ottawa, ON, Canada.
Bhawani JainDepartment of Biochemistry, University of Western Ontario, London, ON, Canada.
Allan W ChenDepartment of Biochemistry, University of Western Ontario, London, ON, Canada.
Karen NygardBiotron Integrated Microscopy Facility, University of Western Ontario, London, ON, Canada.
Cun LiDepartment of Animal Science, University of Wyoming, Laramie, WY, USA.
Peter W NathanielszDepartment of Animal Science, University of Wyoming, Laramie, WY, USA.
Thomas JanssonDepartment of Obstetrics and Gynecology, Division of Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Madhulika B GuptaDepartment of Biochemistry, University of Western Ontario, London, ON, Canada.ORCID https://orcid.org/0000-0001-9197-0341
Western University · CAUniversity of Wyoming · USCarleton University · CAUniversity of Colorado Anschutz Medical Campus · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
PARTURITION AND FETAL PRIMATE HYPOTHALAMIC FUNCTIONP01HD021350 · NICHD · UNIVERSITY OF WYOMING · PI NIJLAND, MARK J · 1987 to 2018
$19.9M
IGFBP-1 hyperphosphorylation in IUGR: Role of mTOR and CK2R03HD078313 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GUPTA, MADHULIKA, JANSSON, THOMAS · 2014 to 2015
$147k
Regulation of IGFBP-1 Phosphorylation in Fetal DevelopmentR03HD093950 · NICHD · UNIVERSITY OF COLORADO DENVER · PI GUPTA, MADHULIKA, JANSSON, THOMAS · 2018 to 2019
$144k
NICHD NIH HHS P01 HD021350NICHD NIH HHS R03 HD078313NICHD NIH HHS R03 HD093950NIH HHS P51 OD011133
6 · The paper itself

Abstract

Hypoxia increases fetal hepatic insulin-like growth factor binding protein-1 (IGFBP-1) phosphorylation mediated by mechanistic target of rapamycin (mTOR) inhibition. Whether maternal nutrient restriction (MNR) causes fetal hypoxia remains unclear. We used fetal liver from a baboon (Papio sp.) model of intrauterine growth restriction due to MNR (70% global diet of Control) and liver hepatocellular carcinoma (HepG2) cells as a model for human fetal hepatocytes and tested the hypothesis that mTOR-mediated IGFBP-1 hyperphosphorylation in response to hypoxia requires hypoxia-inducible factor-1α (HIF-1α) and regulated in development and DNA-damage responses-1 (REDD-1) signaling. Western blotting (n = 6) and immunohistochemistry (n = 3) using fetal liver indicated greater expression of HIF-1α, REDD-1 as well as erythropoietin and its receptor, and vascular endothelial growth factor at GD120 (GD185 term) in MNR versus Control. Moreover, treatment of HepG2 cells with hypoxia (1% pO

Indexed as

Cell Culture TechniquesDisease Models, AnimalAnimalsErythropoietinFetal Growth RetardationFetal WeightFetusHep G2 CellsHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitInsulin-Like Growth Factor Binding Protein 1In Vitro TechniquesMechanistic Target of Rapamycin Complex 1Microscopy, FluorescenceOrgan SizeDDIT4 protein, humanErythropoietinHypoxia-Inducible Factor 1, alpha SubunitInsulin-Like Growth Factor Binding Protein 1Mechanistic Target of Rapamycin Complex 1Protein Kinase C-alphaReceptors, ErythropoietinTranscription FactorsVascular Endothelial Growth Factor Afetal growthfetal hypoxiahypoxia-inducible factor 1mechanistic target of rapamycin complex 1non-human primateregulated in development and DNA damage responses 1

Identifiers

PMID34425031
PMCPMC8428798
OpenAlexW3195070871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.