Evidence map›Paper›PMID 34424949›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2022

Atypical Intrinsic Hemispheric Interaction Associated with Autism Spectrum Disorder Is Present within the First Year of Life.

Max Rolison, Cheryl Lacadie, Katarzyna Chawarska, Marisa Spann, Dustin Scheinost

Open access · bronzeAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Max RolisonDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA.
Cheryl LacadieDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA.
Katarzyna ChawarskaChild Study Center, Yale School of Medicine, New Haven, CT 06519, USA.
Marisa SpannDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY 10032, USA.
Dustin ScheinostDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-6301-1167
Yale University · USColumbia University Irving Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Statistical Analysis CoreP50MH115716 · NIMH · YALE UNIVERSITY · PI MENT, LAURA R. · 2017 to 2021
$11.5M
Translational Developmental Neuroscience of AutismK23MH087770 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DI MARTINO, ADRIANA · 2010 to 2013
$644k
Enhancing the Autism Brain Imaging Data Exchange to Define the Autism ConnectomeR21MH107045 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DI MARTINO, ADRIANA · 2015 to 2016
$479k
Enhancement of the 1000 Functional Connectome ProjectR03MH096321 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI BISWAL, BHARAT BHUSAN, MILHAM, MICHAEL PETER · 2012 to 2013
$158k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K23 MH087770NIMH NIH HHS P50 MH115716NIMH NIH HHS R03 MH096321NIMH NIH HHS R21 MH107045
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is characterized by atypical connectivity lateralization of functional networks. However, previous studies have not directly investigated if differences in specialization between ASD and typically developing (TD) peers are present in infancy, leaving the timing of onset of these differences relatively unknown. We studied the hemispheric asymmetries of connectivity in children with ASD and infants later meeting the diagnostic criteria for ASD. Analyses were performed in 733 children with ASD and TD peers and in 71 infants at high risk (HR) or normal risk (NR) for ASD, with data collected at 1 month and 9 months of age. Comparing children with ASD (n = 301) to TDs (n = 432), four regions demonstrated group differences in connectivity: posterior cingulate cortex (PCC), posterior superior temporal gyrus, extrastriate cortex, and anterior prefrontal cortex. At 1 month, none of these regions exhibited group differences between ASD (n = 10), HR-nonASD (n = 15), or NR (n = 18) infants. However, by 9 months, the PCC and extrastriate exhibited atypical connectivity in ASD (n = 11) and HR-nonASD infants (n = 24) compared to NR infants (n = 22). Connectivity did not correlate with symptoms in either sample. Our results demonstrate that differences in network asymmetries associated with ASD risk are observable prior to the age of a reliable clinical diagnosis.

Indexed as

Autism Spectrum DisorderBrainBrain MappingChildHumansInfantMagnetic Resonance ImagingNeural Pathwaysdata-drivenfunctional connectivityfunctional MRIresting-state

Identifiers

PMID34424949
PMCPMC8924430
OpenAlexW3195346419

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.