Evidence map›Paper›PMID 34424832›Full record

ArticleGut microbes

Early life gut microbiota is associated with rapid infant growth in Hispanics from Southern California.

Tanya L Alderete, Roshonda B Jones, Justin P Shaffer, Elizabeth A Holzhausen, William B Patterson, Elham Kazemian, Lida Chatzi, Rob Knight, Jasmine F Plows, Paige K Berger and 1 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. A Systematic Review to Reassess the Formula for Early Life Growth.Advances in nutrition (Bethesda, Md.) · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Tanya L AldereteDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0002-7751-9543
Roshonda B JonesDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Justin P ShafferDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Elizabeth A HolzhausenDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0002-1773-0099
William B PattersonDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0001-8355-0857
Elham KazemianDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Lida ChatziDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0975-9019
Jasmine F PlowsDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Paige K BergerDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Michael I GoranDepartment of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Children's Hospital of Los Angeles · USUniversity of Colorado Boulder · USUniversity of California San Diego · USUniversity of Southern California · US

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Impact of Sugars and Human Milk Oligosaccharides on Infant Microbiome and ObesityR01DK110793 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC, PETERSON, BRADLEY S · 2017 to 2024
$6.0M
Near-Roadway and Ambient Air Pollution Exposure and the Gut Microbiome: Implications for Obesity and Insulin Resistance in AdolescenceR00ES027853 · NIEHS · UNIVERSITY OF COLORADO · PI ALDERETE, TANYA LYNN · 2018 to 2020
$721k
Role of Human Milk Oligosaccharides on Brain Development in Preterm InfantsR00HD098288 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BERGER, PAIGE KIMBERLY · 2022 to 2024
$686k
Role of Human Milk Oligosaccharides on Infant Brain DevelopmentK99HD098288 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BERGER, PAIGE KIMBERLY · 2020 to 2021
$180k
NICHD NIH HHS K99 HD098288NICHD NIH HHS R00 HD098288NIDDK NIH HHS R01 DK110793NIEHS NIH HHS R00 ES027853NIGMS NIH HHS K12 GM068524
6 · The paper itself

Abstract

We aimed to determine if the newborn gut microbiota is an underlying determinant of early life growth trajectories. 132 Hispanic infants were recruited at 1-month postpartum. The infant gut microbiome was characterized using 16S rRNA amplicon sequencing. Rapid infant growth was defined as a weight-for-age z-score (WAZ) change greater than 0.67 between birth and 12-months of age. Measures of infant growth included change in WAZ, weight-for-length z-score (WLZ), and body mass index (BMI) z-scores from birth to 12-months and infant anthropometrics at 12-months (weight, skinfold thickness). Of the 132 infants, 40% had rapid growth in the first year of life. Multiple metrics of alpha-diversity predicted rapid infant growth, including a higher Shannon diversity (OR = 1.83; 95% CI: 1.07-3.29;

Indexed as

BacteriaBiodiversityBody Mass IndexBody WeightCaliforniaChild DevelopmentFemaleGastrointestinal MicrobiomeHispanic or LatinoHumansInfantInfant, NewbornMothersObesityRNA, Ribosomal, 16SRNA, Ribosomal, 16Sgrowth trajectoriesgut microbiotahispanicsInfant growthobesity

Identifiers

PMID34424832
PMCPMC8386720
OpenAlexW3194853056

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.