Evidence map›Paper›PMID 34424821›Full record

ArticleBioengineered2021

Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aβ

Yiyun Ding, Hongxia Zhang, Zhaojun Liu, Qiuping Li, Yujiao Guo, Ye Chen, Yue Chang, Hongyan Cui

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 35 citations in OpenAlex.

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  8. Mitochondrial heterogeneity in diseases.Signal transduction and targeted therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yiyun DingDepartment of Geriatrics, The Second Hospital of Tianjin Medical University, Tianjin, China.
Hongxia ZhangLaboratory Division, Ankang Center for Disease Control and Prevention, Ankang, Shaanxi Province, China.
Zhaojun LiuDepartment of Geriatrics, The Second Hospital of Tianjin Medical University, Tianjin, China.
Qiuping LiDepartment of Geriatrics, The Second Hospital of Tianjin Medical University, Tianjin, China.
Yujiao GuoDepartment of Geriatrics, The Second Hospital of Tianjin Medical University, Tianjin, China.
Ye ChenDepartment of Geriatrics, The Second Hospital of Tianjin Medical University, Tianjin, China.
Yue ChangDepartment of Geriatrics, The Second Hospital of Tianjin Medical University, Tianjin, China.
Hongyan CuiDepartment of Geriatrics, The Second Hospital of Tianjin Medical University, Tianjin, China.
Second Hospital of Tianjin Medical University · CNTianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CPT1C, which is expressed in hippocampus, influences ceramide level, endogenous cannabinoid and oxidation process, as well as plays an important role in various brain functions such as learning. This study aimed to investigate the role of CPT1C in Alzheimer's disease (AD) and its underlying mechanism. We established a model of Alzheimer's disease in vitro by exposing primary hippocampal neurons to beta-Amyloid peptide fragment 25-35 (Aβ

Indexed as

Carnitine O-PalmitoyltransferaseAmyloid beta-PeptidesAnimalsApoptosisCell LineHippocampusMiceNeuronsOxidative StressPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (25-35)Carnitine O-PalmitoyltransferaseCPT1B protein, mousePeptide FragmentsAlzheimer’s diseaseAβCPT1Chippocampal neurons

Identifiers

PMID34424821
PMCPMC8806834
OpenAlexW3193635743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.