Evidence map›Paper›PMID 34424752›Full record

ArticleInfection and immunity2021

Activity of CcpA-Regulated GH18 Family Glycosyl Hydrolases That Contributes to Nutrient Acquisition and Fitness in Enterococcus faecalis.

Erica C Keffeler, Vijayalakshmi S Iyer, Andrew J Henderson, Ian L Huck, Nancy Schwarting, Analaura Cortez, Lynn E Hancock

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Adaptation ofmSystems · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Metabolism of Poly-β1,4-Journal of bacteriology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Erica C KeffelerDepartment of Molecular Biosciences, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.
Vijayalakshmi S IyerDivision of Biology, Kansas State University, Manhattan, Kansas, USA.
Andrew J HendersonDivision of Biology, Kansas State University, Manhattan, Kansas, USA.
Ian L HuckDivision of Biology, Kansas State University, Manhattan, Kansas, USA.
Nancy SchwartingDepartment of Molecular Biosciences, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.
Analaura CortezDepartment of Molecular Biosciences, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.
Lynn E HancockDepartment of Molecular Biosciences, University of Kansasgrid.266515.3, Lawrence, Kansas, USA.ORCID 0000-0003-3372-5406
University of Kansas · USKansas State University · US

Funding

MBRS IMSD PROGRAM AT THE UNIVERSITY OF KANSASR25GM062232 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI CARTWRIGHT, PAULYN, HANSON, PAUL R. · 2001 to 2018
$6.9M
The regulation of autolysis in Enterococcus faecalisR01AI077782 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI HANCOCK, LYNN E · 2010 to 2014
$1.4M
The role of peptide signaling in Enterococcus faecalis biofilm developmentR21AI117424 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI HANCOCK, LYNN E · 2017 to 2018
$407k
NIAID NIH HHS R01 AI077782NIAID NIH HHS R21 AI117424NIGMS NIH HHS R25 GM062232NIGMS NIH HHS R25GM062232
6 · The paper itself

Abstract

The ability of Enterococcus faecalis to colonize host anatomical sites is dependent on its adaptive response to host conditions. Three glycosyl hydrolase gene clusters, each belonging to glycosyl hydrolase family 18 (GH18) (

Indexed as

Bacterial ProteinsBiofilmsCatalytic DomainEnterococcus faecalisGene Expression Regulation, BacterialGlycoside HydrolasesMannoseNutrientsPolysaccharidesRibonucleasesTranscription Initiation SiteBacterial ProteinsGlycoside HydrolasesMannoseNutrientsPolysaccharidesribonuclease BRibonucleasesCcpAEnterococcus faecalisGH18 familyglycosyl hydrolaseIgGRNase BUTI

Identifiers

PMID34424752
PMCPMC8519268
OpenAlexW3195360801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.