Evidence map›Paper›PMID 34424712›Full record

ArticleJournal of the American Chemical Society2021

Nanoscale Metal-Organic Framework Confines Zinc-Phthalocyanine Photosensitizers for Enhanced Photodynamic Therapy.

Taokun Luo, Geoffrey T Nash, Ziwan Xu, Xiaomin Jiang, Jianqiao Liu, Wenbin Lin

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Taokun LuoDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.
Geoffrey T NashDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.
Ziwan XuDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.
Xiaomin JiangDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0001-8304-4938
Jianqiao LiuDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.
Wenbin LinDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0001-7035-7759

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
Nanoscale Metal-organic Frameworks for Light Triggered and X-ray Induced Photodynamic Therapy of Head and Neck CancersU01CA198989 · NCI · UNIVERSITY OF CHICAGO · PI LIN, WENBIN, WEICHSELBAUM, RALPH R · 2015 to 2019
$3.0M
Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck CancersR01CA253655 · NCI · UNIVERSITY OF CHICAGO · PI LIN, WENBIN, WEICHSELBAUM, RALPH R · 2020 to 2024
$2.5M
NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA253655NCI NIH HHS U01 CA198989
6 · The paper itself

Abstract

The performance of photodynamic therapy (PDT) depends on the solubility, pharmacokinetic behaviors, and photophysical properties of photosensitizers (PSs). However, highly conjugated PSs with strong reactive oxygen species (ROS) generation efficiency tend to have poor solubility and aggregate in aqueous environments, leading to suboptimal PDT performance. Here, we report a new strategy to load highly conjugated but poorly soluble zinc-phthalocyanine (ZnP) PSs in the pores of a Hf

Indexed as

AnimalsBiocompatible MaterialsCell Line, TumorCell SurvivalIsoindolesLysosomesMetal-Organic FrameworksMiceMice, Inbred BALB CMicroscopy, ConfocalNanostructuresNeoplasmsOrganometallic CompoundsPhotochemotherapyPhotosensitizing AgentsReactive Oxygen SpeciesBiocompatible MaterialsIsoindolesMetal-Organic FrameworksOrganometallic CompoundsPhotosensitizing AgentsReactive Oxygen SpeciesZinc CompoundsZn(II)-phthalocyanine

Identifiers

PMID34424712
PMCPMC8414475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.