Evidence map›Paper›PMID 34424711›Full record

ArticleJournal of medicinal chemistry2021

Potent Inhibition of Nicotinamide

Yongzhi Gao, Matthijs J van Haren, Ned Buijs, Paolo Innocenti, Yurui Zhang, Davide Sartini, Roberto Campagna, Monica Emanuelli, Richard B Parsons, Willem Jespers and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Yongzhi GaoBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.
Matthijs J van HarenBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.ORCID 0000-0003-0251-071X
Ned BuijsBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.
Paolo InnocentiBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.
Yurui ZhangBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.
Davide SartiniDepartment of Clinical Sciences, Universitá Politecnica delle Marche, Via Ranieri 65, 60131 Ancona, Italy.
Roberto CampagnaDepartment of Clinical Sciences, Universitá Politecnica delle Marche, Via Ranieri 65, 60131 Ancona, Italy.
Monica EmanuelliDepartment of Clinical Sciences, Universitá Politecnica delle Marche, Via Ranieri 65, 60131 Ancona, Italy.
Richard B ParsonsInstitute of Pharmaceutical Science, King's College London, London SE1 9NH, United Kingdom.
Willem JespersDrug Discovery and Safety, Leiden Academic Center for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
Hugo Gutiérrez-de-TeránDepartment of Cell and Molecular Biology, Uppsala University, Uppsala 75124, Sweden.ORCID 0000-0003-0459-3491
Gerard J P van WestenDrug Discovery and Safety, Leiden Academic Center for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands.ORCID 0000-0003-0717-1817
Nathaniel I MartinBiological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands.ORCID 0000-0001-8246-3006
Leiden University · NLMarche Polytechnic University · ITUppsala University · SECentre for Human Drug Research · NLKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinamide

Indexed as

Enzyme InhibitorsGene Expression Regulation, EnzymologicHumansMolecular StructureNiacinamideNicotinamide N-MethyltransferaseProtein BindingStructure-Activity RelationshipEnzyme InhibitorsN(1)-methylnicotinamideNiacinamideNicotinamide N-Methyltransferase

Identifiers

PMID34424711
PMCPMC8436214
OpenAlexW3194122614

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.