ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2022
The impact of multimorbidity patterns on health-related quality of life in the general population: results of the Belgian Health Interview Survey.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Quality of life and multiple long-term conditions in Southeast Asia: a systematic review and meta-analysis.Nature communications · 2026Pooled it
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- Geriatric syndromes, multimorbidity, and life satisfaction among older adults in India: a cross-sectional analysis of the Longitudinal Ageing Study in India (LASI).Research square · 2026Article
- Quality of life among women of reproductive age during the accumulation of multiple chronic conditions.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Impact of multimorbidity on change in quality of life in a multi-ethnic Asian population: a longitudinal study.Health and quality of life outcomes · 2026Article
- Quality of life, care needs and priorities in atrial fibrillation: the impact of number and patterns of comorbidities.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- The role of comorbidity and frailty in shaping the burden of atrial fibrillation: a multinational cross-sectional survey.Scientific reports · 2026Article
- Burden of chronic diseases and associated risk factors among adults in Saudi Arabia: results from a national telephone survey.BMC public health · 2026Article
- Net effects of correlated determinants of health among U.S. older adults.BMC geriatrics · 2025Article
- Multimorbidity and the indirect cost of productivity loss from health-related work absenteeism in Belgium.European journal of public health · 2025Observational
- Association of socioeconomic and lifestyle factors with the prevalence of chronic noncommunicable disease multimorbidity in rural Southwest China: a structural equation modeling approach.Archives of public health = Archives belges de sante publique · 2025Article
- Clinical and academic nurses' perspectives on the current syllabus related to the management of multimorbidity in teaching curriculum: A qualitative study in Odisha, India.Journal of family medicine and primary care · 2025Article
- Chronic disease clusters and health-related quality of life among individuals with musculoskeletal pain: a Northern Finland Birth Cohort 1966 study.Family practice · 2025Article
- Multimorbidity Management: A Scoping Review of Interventions and Health Outcomes.International journal of environmental research and public health · 2025Article
- Defining patient-reported outcomes in diabetes, obesity, cardiovascular disease, and chronic kidney disease for clinical practice guidelines - perspectives of the taskforce of the Guideline Workshop.Cardiovascular diabetology · 2025Article
- Determinants of oral health-related quality of life in orthodontic aligner wearers: A cross-sectional analysis.PloS one · 2025Article
- Longitudinal study on health-related quality of life and multimorbidity: from trajectories to outcomes in China.Frontiers in public health · 2025Article
- The importance of including a mental health dimension in a multimorbidity indicator: an analysis of Belgian health survey data.BMC public health · 2024Article
- Cross-cultural adaptation and validation of the caregiver self-efficacy in contributing to patient self-care scale in China.BMC public health · 2024Article
- Quality of life of dermatology outpatients and its associated factors in Halibet National Referral Hospital in Asmara, Eritrea.Scientific reports · 2024Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic diseases and multimorbidity are a major cause of disease burden-for patients, caregivers, and society. Little is known however about potential interaction effects between specific disease combinations. Besides an additive effect, the presence of multiple conditions could also act synergistically or antagonistically regarding the impact on patients' health-related quality of life (HRQoL). The aim was to estimate the impact of coexisting chronic diseases on HRQoL of the adult general Belgian population.
methodsThe Belgian Health Interview Survey 2018 provided data on self-reported chronic conditions and HRQoL (EQ-5D-5L) for a nationally representative sample. Linear mixed models were used to analyze two-way and three-way interactions of disease combinations on HRQoL.
resultsMultimorbidity had a prevalence of 46.7% (≥ 2 conditions) and 29.7% (≥ 3 conditions). HRQoL decreased considerably with the presence of multiple chronic diseases. 14 out of 41 dyad combinations and 5 out of 13 triad combinations showed significant interactions, with a dominant presence of negative/synergistic effects. Positive/antagonistic effects were found in more subjective chronic diseases such as depression and chronic fatigue. Conditions appearing the most frequently in significant disease pair interactions were dorsopathies, respiratory diseases, and arthropathies.
conclusionsDiverse multimorbidity patterns, both dyads and triads, were synergistically or antagonistically associated with lower HRQoL. Tackling the burden of multimorbidity is needed, especially because most disease combinations affect each other synergistically, resulting in a greater reduction in HRQoL. Further knowledge about those multimorbidity patterns with a greater impact on HRQoL is needed to better understand disease burden beyond mortality and morbidity data.
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