Evidence map›Paper›PMID 34424483›Full record

ArticleJournal of fluorescence2021

Versatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti-biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities.

Selin S Suner, Mehtap Sahiner, Ramesh S Ayyala, Venkat R Bhethanabotla, Nurettin Sahiner

Abstract read
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Article in Journal of fluorescence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 65 citations in OpenAlex.

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  16. Carbon Dots for Killing Microorganisms: An Update since 2019.Pharmaceuticals (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Selin S SunerDepartment of Chemistry, Faculty of Sciences & Arts, and Nanoscience and Technology Research and Application Center (NANORAC), Canakkale Onsekiz Mart University Terzioglu Campus, Canakkale, 17100, Turkey.
Mehtap SahinerDepartment of Fashion Design, Faculty of Canakkale School of Applied Science, Canakkale Onsekiz Mart University Terzioglu Campus, Canakkale, 17100, Turkey.
Ramesh S AyyalaDepartment of Ophthalmology, University of South Florida, Tampa, 33620, FL, USA.
Venkat R BhethanabotlaDepartment of Ophthalmology, University of South Florida, Tampa, 33620, FL, USA.
Nurettin SahinerDepartment of Chemistry, Faculty of Sciences & Arts, and Nanoscience and Technology Research and Application Center (NANORAC), Canakkale Onsekiz Mart University Terzioglu Campus, Canakkale, 17100, Turkey. sahiner71@gmail.com.ORCID http://orcid.org/0000-0003-0120-530X
Çanakkale Onsekiz Mart Üniversitesi · TRUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanostructured fluorescent particles derived from natural molecules were prepared by a green synthesis technique employing a microwave method. The precursors citric acid (CA) and cysteine (Cys) were used in the preparation of S- and N-doped Cys carbon dots (Cys CDs). Synthesis was completed in 3 min. The graphitic structure revealed by XRD analysis of Cys CDs dots had good water dispersity, with diameters in the range of 2-20 nm determined by TEM analysis. The isoelectric point of the S, N-doped CDs was pH value for 5.2. The prepared Cys CDs displayed excellent fluorescence intensity with a high quantum yield of 75.6 ± 2.1%. Strong antimicrobial capability of Cys CDs was observed with 12.5 mg/mL minimum bactericidal concentration (MBC) against gram-positive and gram-negative bacteria with the highest antimicrobial activity obtained against Staphylococcus aureus. Furthermore, Cys CDs provided total biofilm eradication and inhibition abilities against Pseudomonas aeruginosa at 25 mg/mL concentration. Cys CDs are promising antioxidant materials with 1.3 ± 0.1 μmol Trolox equivalent/g antioxidant capacity. Finally, Cys CDs were also shown to inhibit the acetylcholinesterase (AChE) enzyme, which is used in the treatment of Alzheimer's disease, even at the low concentration of 100 μg/mL.

Indexed as

AcetylcholinesteraseAnti-Bacterial AgentsAntioxidantsBenzothiazolesBiofilmsCarbonCholinesterase InhibitorsCitric AcidCysteineFluorescent DyesHumansPseudomonas aeruginosaQuantum DotsStaphylococcus aureusSulfonic Acids2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acidAcetylcholinesteraseAnti-Bacterial AgentsAntioxidantsBenzothiazolesCarbonCholinesterase InhibitorsCitric AcidCysteineFluorescent DyesSulfonic AcidsAcetylcholinesterase enzyme inhibitorAnti-biofilmAntimicrobialAntioxidantCysteine-based carbon dots

Identifiers

PMID34424483
OpenAlexW3193737374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.