Trial reportEmerging infectious diseases2021
Geographically Targeted Interventions versus Mass Drug Administration to Control Taenia solium Cysticercosis, Peru.
Trial report in Emerging infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- A Multiphase Implementation of Ring Treatment: A Community-Engaged Control Program for T. Solium taeniasis/cysticercosis in Northern Peru.Research square · 2026Article
- Taenia solium neurocysticercosis: Its current epidemiological, diagnostic, therapeutic, and control landscapes.PLoS neglected tropical diseases · 2026Review
- Evaluation of a One Health public health program based on minimum inputs to control Taenia solium in Madagascar.PLoS neglected tropical diseases · 2025Article
- Age at infection as a key predictor of cyst burden in pigs experimentally infected with Taenia solium.Parasites & vectors · 2025Article
- One Health policy communities' perspectives on zoonoses risk factors and management: A multiple qualitative methods approach.CABI one health · 2025Article
- Mass chemotherapy with niclosamide for the control ofLancet regional health. Americas · 2024Article
- Could a ring treatment approach be proposed to control Taenia solium transmission in a post elimination setting? A pilot study in Zambia.PLoS neglected tropical diseases · 2024Article
- In vitro activity of the anthelmintic drug niclosamide against Sporothrix spp. strains with distinct genetic and antifungal susceptibility backgrounds.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Spatial and Temporal Changes inVeterinary medicine international · 2024Article
- Antibody Banding Patterns on the Enzyme-Linked Immunoelectrotransfer Blot (EITB) Assay Clearly Discriminate Viable Cysticercosis in Naturally Infected Pigs.Pathogens (Basel, Switzerland) · 2023Article
- Spatial transferability of an agent-based model to simulate Taenia solium control interventions.Parasites & vectors · 2023Article
- Article
- Global research on cysticercosis and neurocysticercosis: A bibliometric analysis.Frontiers in veterinary science · 2023Article
- Movements of free-range pigs in rural communities in Zambia: an explorative study towards future ring interventions for the control of Taenia solium.Parasites & vectors · 2022Article
- Spatial distribution and risk factors for human cysticercosis in Colombia.Parasites & vectors · 2021Article
- Validation of a spatial agent-based model for Taenia solium transmission ("CystiAgent") against a large prospective trial of control strategies in northern Peru.PLoS neglected tropical diseases · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Optimal control strategies for Taenia solium taeniasis and cysticercosis have not been determined. We conducted a 2-year cluster randomized trial in Peru by assigning 23 villages to 1 of 3 geographically targeted intervention approaches. For ring screening (RS), participants living near pigs with cysticercosis were screened for taeniasis; identified cases were treated with niclosamide. In ring treatment (RT), participants living near pigs with cysticercosis received presumptive treatment with niclosamide. In mass treatment (MT), participants received niclosamide treatment every 6 months regardless of location. In each approach, half the villages received targeted or mass oxfendazole for pigs (6 total study arms). We noted significant reductions in seroincidence among pigs in all approaches (67.1% decrease in RS, 69.3% in RT, 64.7% in MT; p<0.001), despite a smaller proportion of population treated by targeted approaches (RS 1.4%, RT 19.3%, MT 88.5%). Our findings suggest multiple approaches can achieve rapid control of T. solium transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.