Evidence map›Paper›PMID 34424052›Full record

ArticleEnvironmental health perspectives2021

Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model.

Qinghai Liu, Kristina Shkirkova, Krista Lamorie-Foote, Michelle Connor, Arati Patel, Robin Babadjouni, Mikko Huuskonen, Axel Montagne, Hans Baertsch, Hongqiao Zhang and 8 more

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Inhaled Pollutants of the Gero-Exposome and Later-Life Health.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Review
  12. Article
  13. Article
  14. A brief overview of a mouse model of cerebral hypoperfusion by bilateral carotid artery stenosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Qinghai LiuZilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
Kristina ShkirkovaZilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
Krista Lamorie-FooteZilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
Michelle ConnorDepartment of Neurosurgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Arati PatelDepartment of Neurological Surgery, University of California San Francisco School of Medicine, San Francisco, California, USA.
Robin BabadjouniDepartment of Neurological Surgery, Cedars-Sinai, Los Angeles, California, USA.
Mikko HuuskonenZilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
Axel MontagneZilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
Hans BaertschZilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
Hongqiao ZhangLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Jiu-Chiuan ChenDepartment of Preventative Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.
Wendy J MackDepartment of Preventative Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.
Brian P WalcottDepartment of Neurosurgery, Northshore Neurological Institute, Evanston, Illinois, USA.
Berislav V ZlokovicZilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
Constantinos SioutasDepartment of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA.
Todd E MorganLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Caleb E FinchLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
William J MackZilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA.
University of Southern California · USCedars-Sinai Medical Center · USNorthShore University HealthSystem · USUniversity of California, San Francisco · USWashington University in St. Louis · US

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
The Aging Brain: Vasculature, Ischemia, and BehaviorP01AG012435 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VINTERS, HARRY V. · 1994 to 2012
$26.4M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, FINCH, CALEB E · 2018 to 2022
$11.5M
The role of pericytes in white matter diseaseR01NS100459 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZLOKOVIC, BERISLAV V · 2016 to 2020
$3.6M
Neurotoxicity of Airborne Particles: Role of Chronic Cerebral HypoperfusionR01ES024936 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2015 to 2019
$2.4M
NIA NIH HHS P01 AG012435NIA NIH HHS P01 AG055367NIA NIH HHS P30 AG066530NIEHS NIH HHS R01 ES024936NINDS NIH HHS R01 NS100459
6 · The paper itself

Abstract

backgroundExposure to ambient air pollution particulate matter (PM) is associated with increased risk of dementia and accelerated cognitive loss. Vascular contributions to cognitive impairment are well recognized. Chronic cerebral hypoperfusion (CCH) promotes neuroinflammation and blood-brain barrier weakening, which may augment neurotoxic effects of PM.

objectivesThis study examined interactions of nanoscale particulate matter (nPM; fine particulate matter with aerodynamic diameter

methodsnPM was collected using a particle sampler near a Los Angeles, California, freeway. Mice were exposed to 10 wk of reaerosolized nPM or filtered air (FA) for 150 h. CCH was induced by BCAS surgery. Mice (C57BL/6J males) were randomized to four exposure paradigms:

resultsThe joint DISCUSSION: Our data suggest that nPM and CCH contribute to white matter injury in a synergistic manner in a mouse model. Adverse neurological effects may be aggravated in a susceptible population exposed to air pollution. https://doi.org/10.1289/EHP8792.

Indexed as

Air PollutionWhite MatterAnimalsCerebrovascular CirculationDisease Models, AnimalMaleMiceMice, Inbred C57BLParticulate MatterParticulate Matter

Identifiers

PMID34424052
PMCPMC8382048
OpenAlexW3193468199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.