Evidence map›Paper›PMID 34424049›Full record

ArticleAntimicrobial agents and chemotherapy2021

Core Genome Multilocus Sequence Typing and Prediction of Antimicrobial Susceptibility Using Whole-Genome Sequences of Escherichia coli Bloodstream Infection Isolates.

Ritu Banerjee, Scott A Cunningham, Stephan Beisken, Andreas E Posch, Brian Johnston, James R Johnson, Robin Patel

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ritu Banerjee *Vanderbilt University, Nashville, Tennessee, USA.
Scott A Cunningham *Mayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.
Stephan BeiskenAres Genetics GmbH, Vienna, Austria.
Andreas E PoschAres Genetics GmbH, Vienna, Austria.
Brian JohnstonVeterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota, USA.
James R JohnsonVeterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota, USA.
Robin PatelMayo Clinicgrid.66875.3a, Rochester, Minnesota, USA.ORCID 0000-0001-6344-4141

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
Molecular Detection of Biofilms on Hip and Knee ImplantsR01AR056647 · NIAMS · MAYO CLINIC ROCHESTER · PI PATEL, ROBIN · 2009 to 2020
$4.5M
NIAID NIH HHS UM1 AI104681NIAMS NIH HHS R01 AR056647
6 · The paper itself

Abstract

In total, 50 Escherichia coli bloodstream isolates from the clinical laboratory and 12 E. coli isolates referred for pulsed-field gel electrophoresis (PFGE) were sequenced, assessed for clonality using core genome multilocus sequence typing (cgMLST), and evaluated for genomic susceptibility predictions using ARESdb. Results of sequence typing using whole-genome sequencing (WGS)-based MLST and sequence type (ST)-specific PCR were identical. Overall categorical agreement between genotypic (ARESdb) and phenotypic susceptibility testing for 62 isolates and 11 antimicrobial agents was 91%. Among the referred isolates, high major error rates were found for ceftazidime, cefepime, and piperacillin-tazobactam.

Indexed as

BacteremiaEscherichia coliDisease OutbreaksGenome, BacterialHumansMultilocus Sequence Typingantibiotic susceptibility predictionEscherichia colimolecular typingwhole-genome sequencing

Identifiers

PMID34424049
PMCPMC8522740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.