Evidence map›Paper›PMID 34424044›Full record

ArticleAntimicrobial agents and chemotherapy2021

Evaluation of Susceptibility Testing Methods for Aztreonam and Ceftazidime-Avibactam Combination Therapy on Extensively Drug-Resistant Gram-Negative Organisms.

Ayesha Khan, Samuel G Erickson, Cedric Pettaway, Cesar A Arias, William R Miller, Micah M Bhatti

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  11. DOT-MGA for rapid determination of susceptibility to the combination of Ceftazidime-avibactam and Aztreonam among Enterobacterales.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  12. Article
  13. Review
  14. Improved diagnostic stewardship in carbapenem-resistantJournal of medical microbiology · 2025
    Article
  15. Prevalence of New Delhi Metallo-β-lactamase (blaMolecular biology reports · 2025
    Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ayesha KhanCenter for Antimicrobial Resistance and Microbial Genomics, Division of Infectious Diseases, UTHealth, McGovern Medical School, UTHealth, Houston, Texas, USA.ORCID 0000-0002-0489-0712
Samuel G EricksonCenter for Antimicrobial Resistance and Microbial Genomics, Division of Infectious Diseases, UTHealth, McGovern Medical School, UTHealth, Houston, Texas, USA.
Cedric PettawayCenter for Antimicrobial Resistance and Microbial Genomics, Division of Infectious Diseases, UTHealth, McGovern Medical School, UTHealth, Houston, Texas, USA.
Cesar A AriasCenter for Antimicrobial Resistance and Microbial Genomics, Division of Infectious Diseases, UTHealth, McGovern Medical School, UTHealth, Houston, Texas, USA.
William R MillerCenter for Antimicrobial Resistance and Microbial Genomics, Division of Infectious Diseases, UTHealth, McGovern Medical School, UTHealth, Houston, Texas, USA.ORCID 0000-0002-1518-2973
Micah M BhattiDepartment of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Centergrid.240145.6, Houston, Texas, USA.ORCID 0000-0001-5857-5825
The University of Texas Health Science Center at Houston · USThe University of Texas MD Anderson Cancer Center · USUniversity of Texas Health Science Center at Dallas · US

Funding

Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HAAG, ANTHONY · 2020 to 2025
$12.0M
VENOUS: A translational study of enterococcal bacteremiaR01AI148342 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2020 to 2024
$3.9M
The LiaFSR system and antimicrobial peptide resistance in enterococciR01AI134637 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cesar Augusto Arias · 2018 to 2026
$3.7M
Molecular Mechanisms Of Daptomycin Resistance In EnterococciR01AI093749 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2011 to 2015
$1.9M
POR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5M
Role of YxdJK and DAK in the Enterococcal Envelope Stress ResponseK08AI135093 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILLER, WILLIAM R · 2018 to 2022
$929k
NIAID NIH HHS K08 AI135093NIAID NIH HHS K24 AI121296NIAID NIH HHS P01 AI152999NIAID NIH HHS R01 AI093749NIAID NIH HHS R01 AI134637NIAID NIH HHS R01 AI148342
6 · The paper itself

Abstract

Carbapenem-resistant

Indexed as

Anti-Bacterial AgentsAztreonamAzabicyclo Compoundsbeta-LactamasesCeftazidimeDrug CombinationsMicrobial Sensitivity TestsPseudomonas aeruginosaAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsAztreonambeta-LactamasesCeftazidimeDrug Combinationsantibiotic resistanceantimicrobial combinationsbeta-lactamasescarbapenemsclinical methodsdiagnosticsEnterobacteriaceaemetalloenzymesmultidrug resistancesusceptibility testing

Identifiers

PMID34424044
PMCPMC8522751
OpenAlexW3195427433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.