Evidence map›Paper›PMID 34424013›Full record

ArticleDevelopmental psychology2021

Iron deficiency in infancy and neurocognitive and educational outcomes in young adulthood.

Patricia East, Jenalee R Doom, Estela Blanco, Raquel Burrows, Betsy Lozoff, Sheila Gahagan

Open access · greenAbstract read
In one paragraph

Article in Developmental psychology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  8. Association between reticulocyte hemoglobin content (RetHe) and neurodevelopmental outcomes in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Patricia EastDepartment of Pediatrics, University of California, San Diego.ORCID 0000-0002-5169-2735
Jenalee R DoomDepartment of Psychology, University of Denver.ORCID 0000-0003-2857-0817
Estela BlancoDepartment of Pediatrics, University of California, San Diego.ORCID 0000-0002-6232-9210
Raquel BurrowsInstitute of Nutrition and Food Technology, University of Chile.ORCID 0000-0001-9155-0689
Betsy LozoffDepartment of Pediatrics, University of Michigan.ORCID 0000-0002-0399-582X
Sheila GahaganDepartment of Pediatrics, University of California, San Diego.ORCID 0000-0002-1105-7323
University of California San Diego · USUniversity of Chile · CLUniversity of Denver · USUniversity of Michigan · US

Funding

NEUROMATURATION DELAYS IN IRON DEFICIENT ANEMIC INFANTSR01HD033487 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GAHAGAN, SHEILA, LOZOFF, BETSY · 1997 to 2016
$8.8M
Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular RiskR01HL088530 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GAHAGAN, SHEILA · 2008 to 2017
$5.0M
Testing cortisol dysregulation as a mediator between early stress and adolescent cardiovascular healthK01HL143159 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DOOM, JENALEE RAE · 2019 to 2023
$788k
Long-Term Cognitive and Behavioral Effects of Early-Life Iron Deficiency and High-Iron SupplementationR03HD097295 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EAST, PATRICIA L · 2019 to 2020
$126k
NHLBI NIH HHS K01 HL143159NHLBI NIH HHS R01 HL088530NICHD NIH HHS R01 HD033487NICHD NIH HHS R03 HD097295
6 · The paper itself

Abstract

This study examines the extent to which iron deficiency in infancy contributes to adverse neurocognitive and educational outcomes in young adulthood directly and indirectly, through its influence on verbal cognition and attention problems in childhood. Young adults (N = 1,000, M age = 21.3 years, 52% female; of Spanish or indigenous descent) from working-class families in Santiago, Chile, completed instruments assessing memory, processing speed, mental flexibility, and educational attainment. Iron status was assessed at ages 6, 12, and 18 months, and verbal intelligence, inattention, and sluggish cognitive tempo (SCT) symptoms were assessed at age 10. Results indicated that young adults who had iron-deficiency in infancy had poor executive control at age 21. Severity of iron deficiency during infancy was associated with lower verbal IQ and more frequent inattention and SCT symptoms in childhood, and with lower educational attainment in young adulthood through its effect on inattention. No additional indirect effects were found. Interventions directed toward improving cognitive and attention deficits linked to early-life iron deficiency appear warranted and could alter the course to adult functioning. Further research on the impact of such interventions would be helpful. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Indexed as

Anemia, Iron-DeficiencyAdultChildCognitionEducational StatusExecutive FunctionFemaleHumansInfantIntelligenceMaleYoung Adult

Identifiers

PMID34424013
PMCPMC8386013
OpenAlexW3195471029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.