Evidence map›Paper›PMID 34423597›Full record

ArticleJournal of veterinary science2021

Investigation of morphological changes of HPS membrane caused by cecropin B through scanning electron microscopy and atomic force microscopy.

Han Hu, Changsheng Jiang, Binzhou Zhang, Nan Guo, Zhonghua Li, Xiaozhen Guo, Yang Wang, Binlei Liu, Qigai He

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Han Hu *National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, Hubei 430068, China.ORCID https://orcid.org/0000-0002-8188-6143
Changsheng Jiang *State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.ORCID https://orcid.org/0000-0003-1352-8042
Binzhou ZhangState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.ORCID https://orcid.org/0000-0001-7986-8563
Nan GuoState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.ORCID https://orcid.org/0000-0003-0262-8988
Zhonghua LiState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.ORCID https://orcid.org/0000-0003-3564-6576
Xiaozhen GuoState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.ORCID https://orcid.org/0000-0001-6852-6015
Yang WangNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, Hubei 430068, China.ORCID https://orcid.org/0000-0002-9332-5255
Binlei LiuNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, Hubei 430068, China.ORCID https://orcid.org/0000-0001-6210-1585
Qigai HeState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China. he628@mail.hzau.edu.cn.ORCID https://orcid.org/0000-0001-7005-7473
Huazhong Agricultural University · CNHubei University of Technology · CN

Funding

China Agricultural Research System CARS-35China Agriculture Research System of MOF and MARA
6 · The paper itself

Abstract

backgroundAntimicrobial peptides (AMPs) have been identified as promising compounds for consideration as novel antimicrobial agents.

objectivesThis study analyzed the efficacy of cecropin B against

resultsCecropin B exhibited broad inhibition activity against 15 standard

conclusionsBased on the results, cecropin B could inhibit HPS via a pore-forming mechanism by interacting with the cytoplasmic membrane of bacteria. Moreover, as cecropin B concentration increased, the bacteria membrane was more seriously damaged. Thus, cecropin B could be developed as an effective anti-HPS agent for use in clinical applications.

Indexed as

Anti-Infective AgentsAntimicrobial Cationic PeptidesCecropinsCell MembraneHaemophilus parasuisMicrobial Sensitivity TestsMicroscopy, Atomic ForceMicroscopy, Electron, ScanningAnti-Infective AgentsAntimicrobial Cationic PeptidesCecropinsAntimicrobial peptideatomic force microscopyHaemophilus parasuisscanning electron microscopy

Identifiers

PMID34423597
PMCPMC8460462
OpenAlexW3186203528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.