Evidence map›Paper›PMID 34423582›Full record

ArticleBrain and behavior2021

Effect of electroacupuncture on inhibition of inflammatory response and oxidative stress through activating ApoE and Nrf2 in a mouse model of spinal cord injury.

Ni Dai, Chenglin Tang, Hui Liu, Siqin Huang

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ni DaiTraditional Chinese Medicine College, Chongqing Medical University, Chongqing, China.
Chenglin TangTraditional Chinese Medicine College, Chongqing Medical University, Chongqing, China.
Hui LiuInstitute of Neuroscience, Chongqing Medical University, Chongqing, China.
Siqin HuangTraditional Chinese Medicine College, Chongqing Medical University, Chongqing, China.ORCID 0000-0002-9027-4288
Chongqing Medical University · CNZero to Three · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionElectroacupuncture protects neurons and myelinated axons after spinal cord injury by mitigating the inflammatory response and oxidative stress, but how it exerts these effects is unclear. METHODS AND

resultsSpinal cord injury was induced in C57BL/6 wild-type and apolipoprotein E (ApoE) knockout (ApoE

conclusionsThese results suggest that electroacupuncture protects neurons and myelinated axons following spinal cord injury through an ApoE-dependent mechanism.

Indexed as

ElectroacupunctureSpinal Cord InjuriesAnimalsApolipoproteins EMiceMice, Inbred C57BLNF-E2-Related Factor 2Oxidative StressSpinal CordApolipoproteins ENfe2l2 protein, mouseNF-E2-Related Factor 2apolipoprotein Eelectroacupunctureinflammatory responsenuclear factor erythroid 2-related factor 2oxidative stressspinal cord injury

Identifiers

PMID34423582
PMCPMC8442587
OpenAlexW3194307853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.