Evidence map›Paper›PMID 34423579›Full record

ReviewAdvanced healthcare materials2021

Sensing Inflammation Biomarkers with Electrolyte-Gated Organic Electronic Transistors.

Bernhard Burtscher, Pamela Allison Manco Urbina, Chiara Diacci, Simone Borghi, Marcello Pinti, Andrea Cossarizza, Carlo Salvarani, Magnus Berggren, Fabio Biscarini, Daniel T Simon and 1 more

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Brain-Inspired Polymer Dendrite Networks for Morphology-Dependent Computing Hardware.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bernhard BurtscherLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, 60174, Sweden.ORCID 0000-0002-6394-2965
Pamela Allison Manco UrbinaDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, Modena, 41125, Italy.ORCID 0000-0002-3687-9374
Chiara DiacciLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, 60174, Sweden.ORCID 0000-0002-2724-5601
Simone BorghiDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, Modena, 41125, Italy.
Marcello PintiDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, Modena, 41125, Italy.ORCID 0000-0001-9118-1262
Andrea CossarizzaDepartment of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Via Campi 287, Modena, 41125, Italy.ORCID 0000-0002-5381-1558
Carlo SalvaraniRheumatology Unit, University of Modena and Reggio Emilia, Medical School, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, 41124, Italy.
Magnus BerggrenLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, 60174, Sweden.ORCID 0000-0001-5154-0291
Fabio BiscariniDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, Modena, 41125, Italy.ORCID 0000-0001-6648-5803
Daniel T SimonLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, 60174, Sweden.ORCID 0000-0002-2799-3490
Carlo A BortolottiDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, Modena, 41125, Italy.ORCID 0000-0002-5701-5727

Funding

H2020 Marie Skłodowska-Curie Actions 813863Knut and Alice Wallenberg FoundationSwedish Foundation for Strategic Research
6 · The paper itself

Abstract

An overview of cytokine biosensing is provided, with a focus on the opportunities provided by organic electronic platforms for monitoring these inflammation biomarkers which manifest at ultralow concentration levels in physiopathological conditions. Specifically, two of the field's state-of-the-art technologies-organic electrochemical transistors (OECTs) and electrolyte gated organic field effect transistors (EGOFETs)-and their use in sensing cytokines and other proteins associated with inflammation are a particular focus. The overview will include an introduction to current clinical and "gold standard" quantification techniques and their limitations in terms of cost, time, and required infrastructure. A critical review of recent progress with OECT- and EGOFET-based protein biosensors is presented, alongside a discussion onthe future of these technologies in the years and decades ahead. This is especially timely as the world grapples with limited healthcare diagnostics during the Coronavirus disease (COVID-19)pandemic where one of the worst-case scenarios for patients is the "cytokine storm." Clearly, low-cost point-of-care technologies provided by OECTs and EGOFETs can ease the global burden on healthcare systems and support professionals by providing unprecedented wealth of data that can help to monitor disease progression in real time.

Indexed as

Biosensing TechniquesCOVID-19BiomarkersElectrolytesHumansInflammationSARS-CoV-2Transistors, ElectronicBiomarkersElectrolytesbiosensorscytokinesEGOTinflammationorganic bioelectronics

Identifiers

PMID34423579
PMCPMC11469060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.