Evidence map›Paper›PMID 34423482›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2021

Antibacterial Gel Coatings Inspired by the Cryptic Function of a Mussel Byssal Peptide.

Galit Fichman, Caroline Andrews, Nimit L Patel, Joel P Schneider

Open access · greenAbstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 98 citations in OpenAlex.

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  17. Peptide hydrogels for affinity-controlled release of therapeutic cargo: Current and potential strategies.Journal of peptide science : an official publication of the European Peptide Society · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Galit FichmanChemical Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA.ORCID https://orcid.org/0000-0001-5060-0723
Caroline AndrewsCancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA.
Nimit L PatelSmall Animal Imaging Program, Laboratory of Animal Sciences Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD, 21704, USA.ORCID https://orcid.org/0000-0002-8251-7155
Joel P SchneiderChemical Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA.ORCID https://orcid.org/0000-0002-4403-7900
National Institutes of Health · USLeidos (United States) · US

Funding

Development of antibacterial agents and materialsZIABC011314 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHNEIDER, JOEL · 2010 to 2025
$8.9M
Intramural NIH HHS ZIA BC011314NCI NIH HHS
6 · The paper itself

Abstract

Although the adhesive and cohesive nature of mussel byssal proteins have long served to inspire the design of materials embodying these properties, their characteristic amino acid compositions suggest that they might also serve to inspire an unrelated material function not yet associated with this class of protein. Herein, it is demonstrated that a peptide derived from mussel foot protein-5, a key protein in mussel adhesion, displays antibacterial properties, a yet unreported activity. This cryptic function serves as inspiration for the design of a new class of peptide-based antibacterial adhesive hydrogels prepared via self-assembly, which are active against drug-resistant Gram-positive bacteria. The gels exert two mechanisms of action, surface-contact membrane disruption and oxidative killing affected by material-produced H

Indexed as

AnimalsAnti-Bacterial AgentsBivalviaCoated Materials, BiocompatibleGram-Positive BacteriaHydrogelsMicePeptidesProstheses and ImplantsProteinsRheologyTitaniumadhesive protein, musselAnti-Bacterial AgentsCoated Materials, BiocompatibleHydrogelsPeptidesProteinsTitaniumantibacterialbioinspiredhydrogelspeptidesself-assembly

Identifiers

PMID34423482
PMCPMC8492546
OpenAlexW3193651644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.