Evidence map›Paper›PMID 34423378›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2021

Three-way interaction effects of early life stress, positive parenting and FKBP5 in the development of depressive symptoms in a general population.

Rebecka Keijser, Susanne Olofsdotter, Kent W Nilsson, Cecilia Åslund

Open access · hybridAbstract read
In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Recent developments in stress and anxiety research.Journal of neural transmission (Vienna, Austria : 1996) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rebecka KeijserDepartment of Neuroscience, Uppsala University, Uppsala, Sweden. rebecka.keijser@mdh.se.ORCID 0000-0003-1711-9748
Susanne OlofsdotterCentre for Clinical Research, Uppsala University, Västmanland County Hospital Västerås, 721 89, Västerås, Sweden.ORCID 0000-0002-8114-8386
Kent W NilssonDepartment of Neuroscience, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-8853-2508
Cecilia ÅslundCentre for Clinical Research, Uppsala University, Västmanland County Hospital Västerås, 721 89, Västerås, Sweden.ORCID 0000-0002-3589-6113
Uppsala University · SE

Funding

Åke Wiberg Stiftelse M15-0239Stiftelsen Söderström Königska Sjukhemmet SLS-559921Stiftelsen Söderström Königska Sjukhemmet SLS-655791Stiftelsen Söderström Königska Sjukhemmet SLS-745221Working Life and Welfare (FORTE) 2015-00897
6 · The paper itself

Abstract

FKBP5 gene-environment interaction (cG × E) studies have shown diverse results, some indicating significant interaction effects between the gene and environmental stressors on depression, while others lack such results. Moreover, FKBP5 has a potential role in the diathesis stress and differential susceptibility theorem. The aim of the present study was to evaluate whether a cG × E interaction effect of FKBP5 single-nucleotide polymorphisms (SNPs) or haplotype and early life stress (ELS) on depressive symptoms among young adults was moderated by a positive parenting style (PASCQ

Indexed as

Adverse Childhood ExperiencesDepressionAdolescentCohort StudiesGenotypeHumansParentingPolymorphism, Single NucleotideTacrolimus Binding Protein 5Tacrolimus Binding ProteinsYoung AdultTacrolimus Binding Protein 5Tacrolimus Binding ProteinsAdolescencecG × EDiathesis stressDifferential susceptibilityFKBP Prolyl Isomerase 5

Identifiers

PMID34423378
PMCPMC8423649
OpenAlexW3193816203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.