← Statins × cardiovascular events

SynthesisEuropean journal of clinical pharmacology2022

Efficacy of high-dose atorvastatin or rosuvastatin loading in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a meta-analysis of randomized controlled trials with GRADE qualification of available evidence.

Josip A Borovac et al.PubMed ↗Publisher ↗

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with fewer cardiovascular events

−43%−59% to −23%

Bigger than 9 in 10 for cardiovascular events

As reported

RR 0.57, 95% CI 0.41–0.77

Correlation, not cause

Went with fewer cardiovascular events

−33%−52% to −6%

Bigger than 7 in 10 for cardiovascular events

As reported

RR 0.67, 95% CI 0.48–0.94

Correlation, not cause

Went with fewer cardiovascular events

−52%−66% to −34%

Bigger than 9 in 10 for cardiovascular events

As reported

RR 0.48, 95% CI 0.34–0.66

Three numbers in the abstract

the abstract, start to end

… (RR) reduction in MACCE at 30 days (RR 0.57, 95% CI 0.41-0.77) in whole ACS …

… with a 33% reduction in MACCE (RR 0.67, 95% CI 0.48-0.94), while in …

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
RR 0.570.41–0.77
Cardiovascular events
RR 0.670.48–0.94
Cardiovascular events
RR 0.480.34–0.66
StatinsCardiovascular events
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Full record →Abstract, authors, funding and every citing paper · PMID 34423376