Evidence map›Paper›PMID 34423302›Full record

ArticleBrain communications2021

Individualized response to semantic versus phonological aphasia therapies in stroke.

Sigfus Kristinsson, Alexandra Basilakos, Jordan Elm, Leigh Ann Spell, Leonardo Bonilha, Chris Rorden, Dirk B den Ouden, Christy Cassarly, Souvik Sen, Argye Hillis and 2 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 59 citations in OpenAlex.

  1. Trial
  2. Language Recovery after Brain Injury: A Structural Network Control Theory Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Trial
  3. Article
  4. Article
  5. Narrative Discourse Predictors of Response to Naming Intervention in Aphasia.Journal of speech, language, and hearing research : JSLHR · 2026
    Article
  6. Characterizing Verb Argument Structure in Aphasia Using Dependency Parsers.Journal of speech, language, and hearing research : JSLHR · 2026
    Article
  7. Digital Twin Model of Treatment Outcomes in Post-Stroke Aphasia.medRxiv : the preprint server for health sciences · 2026
    Article
  8. Gene Expression-Based Lesion-Symptom Mapping:The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Cognitive Functions Supporting Learning Over Time in Naming Treatment for Aphasia.Journal of speech, language, and hearing research : JSLHR · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. TEleRehabilitation foR Aphasia (TERRA) phase II trial design.Contemporary clinical trials communications · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Sigfus KristinssonDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA.ORCID https://orcid.org/0000-0002-0459-5369
Alexandra BasilakosCenter for the Study of Aphasia Recovery, University of South Carolina, Columbia, SC 29208, USA.
Jordan ElmCenter for the Study of Aphasia Recovery, University of South Carolina, Columbia, SC 29208, USA.
Leigh Ann SpellDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA.
Leonardo BonilhaCenter for the Study of Aphasia Recovery, University of South Carolina, Columbia, SC 29208, USA.
Chris RordenCenter for the Study of Aphasia Recovery, University of South Carolina, Columbia, SC 29208, USA.
Dirk B den OudenDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA.
Christy CassarlyCenter for the Study of Aphasia Recovery, University of South Carolina, Columbia, SC 29208, USA.
Souvik SenCenter for the Study of Aphasia Recovery, University of South Carolina, Columbia, SC 29208, USA.
Argye HillisCenter for the Study of Aphasia Recovery, University of South Carolina, Columbia, SC 29208, USA.
Gregory HickokCenter for the Study of Aphasia Recovery, University of South Carolina, Columbia, SC 29208, USA.
Julius FridrikssonDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA.
University of South Carolina · USMedical University of South Carolina · USJohns Hopkins University · US

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2016 to 2025
$25.0M
Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
NIDCD NIH HHS P50 DC014664NIGMS NIH HHS P20 GM109040
6 · The paper itself

Abstract

Attempts to personalize aphasia treatment to the extent where it is possible to reliably predict individual response to a particular treatment have yielded inconclusive results. The current study aimed to (i) compare the effects of phonologically versus semantically focussed naming treatment and (ii) examine biographical and neuropsychological baseline factors predictive of response to each treatment. One hundred and four individuals with chronic post-stroke aphasia underwent 3 weeks of phonologically focussed treatment and 3 weeks of semantically focussed treatment in an unblinded cross-over design. A linear mixed-effects model was used to compare the effects of treatment type on proportional change in correct naming across groups. Correlational analysis and stepwise regression models were used to examine biographical and neuropsychological predictors of response to phonological and semantic treatment across all participants. Last, chi-square tests were used to explore the association between treatment response and phonological and semantic deficit profiles. Semantically focussed treatment was found to be more effective at the group-level, independently of treatment order (

Indexed as

aphasiaaphasia therapyphonological therapysemantic therapystroke

Identifiers

PMID34423302
PMCPMC8376685
OpenAlexW3188509698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.