Evidence map›Paper›PMID 34423271›Full record

ArticleACS pharmacology & translational science2021

Pharmacological Inhibition of the Voltage-Gated Sodium Channel Na

Yan Jiang, Joel Castro, Linda V Blomster, Akello J Agwa, Jessica Maddern, Gudrun Schober, Volker Herzig, Chun Yuen Chow, Fernanda C Cardoso, Paula Demétrio De Souza França and 6 more

Open access · greenAbstract read
In one paragraph

Article in ACS pharmacology & translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. GABAExperimental physiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. NabioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. Development and Validation of Nerve-Targeted Bacteriochlorin Sensors.Journal of the American Chemical Society · 2023
    Article
  9. Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Yan JiangInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.ORCID https://orcid.org/0000-0001-5277-804X
Joel CastroVisceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, South Australia 5042, Australia.
Linda V BlomsterInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.
Akello J AgwaInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.
Jessica MaddernVisceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, South Australia 5042, Australia.
Gudrun SchoberVisceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, South Australia 5042, Australia.
Volker HerzigInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.
Chun Yuen ChowInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.ORCID https://orcid.org/0000-0003-2861-5843
Fernanda C CardosoInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.ORCID https://orcid.org/0000-0002-0068-9974
Paula Demétrio De Souza FrançaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Junior GonzalesDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
Christina I SchroederInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.ORCID https://orcid.org/0000-0002-6737-6374
Steffen EscheIndependent Consultant, Weissenfels 06667, Germany.
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.ORCID https://orcid.org/0000-0002-7819-5480
Stuart M BrierleyVisceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, South Australia 5042, Australia.
Glenn F KingInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.ORCID https://orcid.org/0000-0002-2308-2200
The University of Queensland · AUFlinders University · AUMemorial Sloan Kettering Cancer Center · USAsklepios Klinik Weißenfels · DEAustralian Research Council · AU

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Development and validation of an intraoperative imaging agent for the peripheral nervous systemR01EB029769 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI PILLARSETTY, NAGAVARAKISHORE · 2020 to 2023
$2.2M
NCI NIH HHS P30 CA008748NIBIB NIH HHS R01 EB029769
6 · The paper itself

Abstract

The human nociceptor-specific voltage-gated sodium channel 1.7 (hNa

Identifiers

PMID34423271
PMCPMC8369682
OpenAlexW3166008885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.