Evidence map›Paper›PMID 34423267›Full record

ArticleACS pharmacology & translational science2021

Fishing for Contact: Modeling Perivascular Glioma Invasion in the Zebrafish Brain.

Robyn A Umans, Mattie Ten Kate, Carolyn Pollock, Harald Sontheimer

Open access · greenAbstract read
In one paragraph

Article in ACS pharmacology & translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Glioblastoma research on zebrafish xenograft models: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Pooled it
  2. Review
  3. Review
  4. The Zebrafish Model in Animal and Human Health Research.International journal of molecular sciences · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Zebrafish Models of Paediatric Brain Tumours.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Robyn A UmansCenter for Glial Biology in Health, Disease, and Cancer, The Fralin Biomedical Research Institute at VTC, Roanoke, Virginia 24016, United States.ORCID 0000-0001-8862-8887
Mattie Ten KateSchool of Neuroscience, Virginia Tech, Sandy Hall, 210 Drillfield Drive, Blacksburg, Virginia 24061, United States.
Carolyn PollockSchool of Neuroscience, Virginia Tech, Sandy Hall, 210 Drillfield Drive, Blacksburg, Virginia 24061, United States.
Harald SontheimerCenter for Glial Biology in Health, Disease, and Cancer, The Fralin Biomedical Research Institute at VTC, Roanoke, Virginia 24016, United States.
Biomedical Research Institute · USVirginia Tech · US

Funding

PROPERTIES AND FUNCTION OF GLIA ION CHANNELSR01NS031234 · NINDS · YALE UNIVERSITY · PI SONTHEIMER, HARALD W · 1994 to 2011
$3.3M
Regulation of Amino-acid Transport in Human GliomasR01CA227149 · NCI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SONTHEIMER, HARALD W · 2019 to 2023
$1.8M
Glioma-Astrocyte Vascular InteractionsR01NS082851 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SONTHEIMER, HARALD W · 2013 to 2016
$1.3M
NCI NIH HHS R01 CA227149NINDS NIH HHS R01 NS031234NINDS NIH HHS R01 NS082851
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is a highly invasive, central nervous system (CNS) cancer for which there is no cure. Invading tumor cells evade treatment, limiting the efficacy of the current standard of care regimen. Understanding the underlying invasive behaviors that support tumor growth may allow for generation of novel GBM therapies. Zebrafish (

Identifiers

PMID34423267
PMCPMC8369679
OpenAlexW3116847351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.